冠狀動脈介入術後患者抗血小板藥物治療的監測

Monitoring the reactivity of antiplatelet therapy in the Patients with undergoing Percutaneous coronary intervention

目的對冠狀動脈介入術後患者應用阿司匹林和P2Y12抑制劑治療期間進行實驗室檢測,探討血小板反應性。方法冠狀動脈介入術後患者服用阿司匹林和P2Y12抑制劑5天或以上,採用VerifyNow檢測血小板聚集功能。結果26例行PCI治療的ACS患者,平均年齡為(72.38±9.17)歲。檢出ARU≧550為19.23%,低反應組與敏感組間年齡、性別、高血壓病的差異無統計學意義。PRU≧230同時P2Y12抑制率<40%為61.54%。結論對PCI後患者抗血小板藥物治療期間的血小板反應性監測應加強。

Objective To discuss the platelet reactivity for testing the patients on aspirin and P2Y12 inhibitors therapy after percutaneous coronary intervention.Methods The Patients took aspirin and P2Y12 inhibitors five days or more after Percutaneous coronary intervention,then testing the platelet aggregation with VerifyNow.Results 26 patients with acute coronary syndrome and undergoing Percutaneous coronary intervention were involved into this study.The average age was 72.38±9.17 years old.ARU≥550 was 19.23%.There was no significance on age,sex and hypertension in the low response group and the sensitive group.PRU≥230 and P2Y12 Inhibition rate<40%was 61.54%.Conclusion We should Strengthen monitoring the platelet reactivity during antiplatelet therapy.