新生兒持續肺動脈高壓臨床分析

Clinical analysis of neonatal persistent pulmonary hypertension

目的總結新生兒持續肺動脈高壓的臨床診療經驗。方法回顧性分析鏡湖醫院2010年1月~2018年12月收治的17例新生兒持續肺動脈高壓患兒的臨床資料。結果本院新生兒持續肺動脈高壓發生率低於文獻報導,患兒以足月兒,剖腹產,男性為多,病因包括酸中毒,圍產期窒息,呼吸窘迫綜合徵,胎糞吸入綜合徵,肺炎等。予機械通氣,配合NO吸入,升壓藥,MgSO_(4),Milrinone,surfactant,sildenafil的綜合治療效果理想。結論鏡湖醫院新生兒持續肺動脈高壓診療情況符合臨床常規,治療效果可。

Objective To summarize the clinical diagnosis and treatment experience of neonatal persistent pulmonary hypertension.Methods The clinical data of 17 cases with neonatal persistent pulmonary hypertension admitted to Kiang Wu hospital from Jan 2010 to Dec 2018 were retrospectively analyzed.Results The incidence of neonatal persistent pulmonary hypertension in Kiang Wu hospital was lower than that of data reports in the literature.Most patients were full-term infants,cesarean section and male.The pathogen included acidosis,perinatal asphyxia,respiratory distress syndrome,meconium aspiration syndrome,pneumonia,etc.The efficacy was very good after comprehensive treatments of mechanical ventilation,including nitric oxide(NO)inhalation,inotropic support,MgSO_(4),Milrinone,surfactant and sildenafil.Conclusion Diagnosis and treatment of neonatal persistent pulmonary hypertension in Kiang Wu hospital was in accordance with the guideline,and the efficacy was acceptable.