宮頸細胞學ASCUS病例行高危型HPV檢測的意義

The significance of high-risk HPV testing in ASCUS cases of cervical cytology

目的研究高危型HPV(HR-HPV)檢測,在意義不明確的不典型鱗狀上皮細胞(ASCUS)中的意義。方法選取ASCUS共370例,行HR-HPV檢測和宮頸組織活檢,並分析它們之間的關係。結果ASCUS的HR-HPV陽性率80.54%(298/370)。組織學陽性率39.46%(146/370)。HR-HPV陽性組中的組織學低級別鱗狀上皮内病變(LSIL)及高級別鱗狀上皮内病變(HSIL)檢出率明顯高於陰性組(P<0.01)。結論ASCUS患者需行HR-HPV檢測,HR-HPV感染者需行宮頸活檢,從而提高LSIL及HSIL的診斷率,以達到宮頸鱗狀上皮内病變的早期發現和預防宮頸癌的目的。

Objective To study the value of high-risk HPV(HR-HPV)test in cases with the atypical squamous cells of undetermined significance(ASCUS).Methods Three hundred seventy cases of ASCUS patients were collected,and HR-HPV test and cervical biopsy were performed.The relationship between them was analyzed.Results HR-HPV positive rate was 80.54%(298/370).The histopathology positive rate was 39.46%(146/370).The low grade squamous intraepithelial lesion(LSIL)and high grade squamous intraepithelial lesion(HSIL)in HR-HPV positive group was significantly higher than in negative group(P<0.01).Conclusion HR-HPV should be tested in ASCUS patients.In case of HR-HPV positive,a cervical biopsy should be done,in order to raise the diagnostic rate of LSIL or HSIL,and prevent cervical carcinoma.