Bmi-1蛋白在鼻咽癌組織中的表達及意義

Expression and significance of Bmi-1protein in nasopharyngeal carcinoma tissue

目的觀察Bmi-1蛋白在鼻咽癌(nasopharyngeal carcinoma,NPC)組織中的表達,探討Bmi-1表達與臨床病理特徵的關係。方法利用免疫組織化學方法檢測103例NPC和80例鼻咽炎症石蠟包埋組織中的Bmi-1表達情況。結果在103例NPC中,33例Bmi-1呈陰性(32.04%),70例呈陽性(67.96%)。在80例鼻咽炎症中,65例Bmi-1呈陰性(81.25%),15例呈陽性(18.75%),NPC的Bmi-1陽性表達率明顯高於鼻咽炎症(P<0.05)。Bmi-1的陽性率與淋巴結轉移(P=0.01)及臨床TNM分期(P=0.01)密切相關,而與患者性別及年齡無關。結論研究結果提示Bmi-1參與NPC的發生、發展及侵襲和轉移過程,陽性表達可以作為NPC預後不良的一項指標。

Objective To investigate the expression of Bmi-1 protein in nasopharyngeal carcinoma(NPC)and explore its associations with clinicopathological features.Methods 103 NPC and 80 inflammatory nasopharyngeal tissue paraffin embedded samples were collected,and their Bmi-1 expression was detected by immunohistochemistry�Results Among 103 NPC tissues,thirty-three cases showed Bmi-1 negative(32.04%),and 70 cases were positive(67.96).In 80 nasopharyngeal inflammatory tissues,65 cases showed Bmi-1 negative(81.25%)and 15 positives(18.75).The Bmi-1 protein expression rate of NPC was significantly higher than that of nasopharyngeal inflammatory tissues(P<0.05).The Bmi-1 protein expression rate of NPC was correlated significantly with lymph node metastasis(P=0.01)and clinical stage(P=0.01),but no significant associations were found with sex and age.Conclusion The results of this study suggest that Bmi-1 is involved in the occurrence,development,invasion and metastasis of NPC.Bmi-1 positive expression can be used as an indicator of the poor prognosis of NPC.