氨甲环酸在创伤救治中的应用研究进展

Development of tranexamic acid for trauma rescue and treatment

氨甲环酸(tranexamic acid,TXA)作为一种抗纤溶药物,在20世纪60年代就已面世,然而随着对该药物的药理作用、临床应用和安全性方面的广泛研究,发现它在创伤患者的救治中起着越来越重要的作用,近年来关于TXA应用的相关研究呈指数级增长,但到目前为止TXA在出血中发挥的确切作用仍不是非常清楚,其在临床上的使用仍存在一些争议与不足。文章综述了近年来氨甲环酸在创伤救治中的应用进展。

Tranexamic acid(TXA)emerged as an antifibrinolytic agent in the 1960s.However,with extensive research on its pharmacological effects,clinical use,and safety,it has been found to play an increasingly important role in the care of trauma patients.In recent years,there has been an exponential increase in relevant studies on the use of TXA,but the exact role played by TXA in hemorrhage is still not very clear,and its use in the clinic remains somewhat controversial and insufficient.Recent advances in the use of tranexamic acid in trauma rescue and treatment were reviewed.