低聚木糖对抗龋齿效果的初步研究

A Primary Study on the Effect of Xylo-oligosaccharide Against Dental Caries

低聚木糖是一种具有较大市场价值的功能性低聚糖,具有较好的耐酸性,难以被消化酶消化,不能被口腔细菌作为底物所利用,作用于蔗糖,可阻止蔗糖被细菌利用,抑制口腔致病菌的生长,具有抗龋齿作用。本文对3种培养基中变异链球菌的生长和产酸情况进行研究,通过模拟口腔环境厌氧培养24 h后,用分光光度计和pH计分别测定3种培养基中的OD((600))值和pH值,验证低聚木糖对口腔变异链球菌的抗龋齿作用。结果表明,低聚木糖能使变异链球菌的生长和产酸受到明显抑制,低聚木糖-蔗糖培养基也会使变异链球菌的生长和产酸能力下降。因此,低聚木糖可作为一种新型防龋齿添加剂。

Xylooligosaccharide is a functional oligosaccharide with great market value. It has good acid resistance,is difficult to be digested by digestive enzymes, and cannot be used as a substrate by oral bacteria. It can prevent sucrose from being used by bacteria, inhibit the growth of oral pathogenic bacteria, and has an anti caries effect. In this paper,the growth and acid production of Streptococcus mutans in three kinds of culture media were studied. After 24 hours of anaerobic culture in simulated oral environment, OD(600)and pH values in three kinds of culture media were measured with spectrophotometer and pH meter to verify the anti caries effect of xylooligosaccharide on oral Streptococcus mutans. The results showed that xylooligosaccharide could significantly inhibit the growth and acid production of Streptococcus mutans,and xylooligosaccharide sucrose medium could also reduce the growth and acid production of Streptococcus mutans.Therefore, xylooligosaccharides can be used as a new anti caries additive.