摘要
近30年来,高毒力肺炎克雷伯菌(hvKP)的检出率不断增加。以往学者们曾一度认为高毒力与耐药性不会在同一株肺炎克雷伯菌(KP)中重叠出现,但近年来hvKP耐药甚至多重耐药的报道越来越多,hvKP的高毒力及其与高耐药性的结合很可能会成为临床面临的重大挑战。文章就hvKP的流行病学特征、检测方法、耐药现状和治疗策略等进行阐述,以期为临床检测和治疗hvKP感染,预防和控制多重耐药hvKP的流行提供参考。
In the past 30 years,hypervirulent Klebsiella pneumoniae(hvKP)isolates have been increasing.Once it was believed that the hypervirulence and high drug resistance would not occur in the same Klebsiella pneumoniae(KP)isolate.However,the recent reports on drug resistance and multi-drug resistance of hvKP isolates have emerged one after another.Therefore,the hypervirulence of hvKP and its combination with multi-drug resistance is likely to become an important clinical challenge.This review focuses on the epidemiology,determination methods,drug resistance and treatment of hvKP,in order to provide a reference for the clinical determination,treatment,prevention and control of multi-drug resistant hvKP.
作者
王粟
丁立
姜文容
缪应新
张艳梅
赵虎
WANG Su;DING Li;JIANG Wenrong;MIAO Yingxin;ZHANG Yanmei;ZHAO Hu(Department of Clinical Laboratory,Huadong Hospital,Fudan University,Shanghai,200040)
出处
《检验医学》
CAS
2023年第1期81-86,共6页
Laboratory Medicine
基金
上海市卫生健康委员会青年课题(20184Y0032)
上海市科学技术委员会科技创新行动计划(18411950800)。
关键词
肺炎克雷伯菌
毒力
耐药
治疗
Klebsiella pneumoniae
Virulence
Drug resistance
Treatment
