泌尿系结石与非酒精性脂肪性肝病相关性的研究进展

Advances in the study of the correlation between urolithiasis and non-alcoholic fatty liver disease

近年来,临床上发现非酒精性脂肪肝患者多伴有泌尿系结石,且随着非酒精性脂肪肝的严重程度增加泌尿系结石的伴发率也呈递增趋势。同时,泌尿系结石患者的非酒精性脂肪性肝病检出率也高于非泌尿系结石对照组。本文回顾国内外有关泌尿系结石与非酒精性脂肪性肝病相关性的研究,介绍相关的发病机制如胰岛素抵抗、氧化应激、脂代谢异常和乙醛酸解毒受损,便于临床早期筛查和诊断。同时,本文针对两种疾病共同的危险因素,包括代谢相关疾病、生活方式和饮食因素提供了相应的预防措施建议,以期降低非酒精性脂肪性肝病相关泌尿系结石的发生和复发风险。

In recent years,researchers have found that patients with nonalcoholic fatty liver disease(NAFLD)often have urolithiasis,and the incidence of urolithiasis increases gradually with the severity of NAFLD.Meanwhile,the detection rate of NAFLD was higher in patients with urolithiasis than in normal controls.In this paper,we reviewed the domestic and international studies on the correlation between urolithiasis and NAFLD and described the related pathogenesis,such as insulin resistance,oxidative stress,abnormal lipid metabolism and impaired glyoxalate detoxification.Meanwhile,this paper proposed preventive measures to reduce the risk of development and recurrence of NAFLD-associated urolithiasis by addressing the common risk factors of both diseases,including metabolism-related diseases,lifestyle and diet.