基于脂质代谢异常探讨“痰浊”理论在肝细胞癌微环境中的生物学内涵

Biological connotation of “phlegm-turbidity” theory in hepatocellular carcinoma microenvironment based on abnormal lipid metabolism

肝癌的防治目前仍缺乏有效策略,对其发病机制的深入认识有助于开发新的治疗手段。由于脂质代谢在肝癌发生发展中的异常改变,其变化过程与中医“痰浊”理论密切相关。本文将从肝细胞癌微环境中脂质代谢变化入手,探讨脂质代谢在肿瘤细胞和免疫细胞群的异常改变与“痰浊”理论的相关性,以及临床应用化痰相关治法所取得的疗效。由于中医“痰浊”理论的致病特性在肝癌发病和病机变化中具有重要作用,因此对其理论内涵的分析有助于病理机制的阐明,也为中医药发挥防治肝癌作用提供理论依据。

There is still a lack of effective strategies for the prevention and treatment of liver cancer,and a deep understanding of its pathogenesis may help to develop new treatment methods.Due to the abnormal changes of lipid metabolism in the development and progression of liver cancer,such process is closely associated with the “phlegm-turbidity” theory in traditional Chinese medicine(TCM).Starting from the changes of lipid metabolism in hepatocellular carcinoma microenvironment,this article discusses the association of the abnormal changes of lipid metabolism in tumor cells and immune cells with the “phlegm-turbidity” theory and the clinical efficacy of phlegm-eliminating therapies in clinical practice.Since the “phlegm-turbidity” theory in TCM plays an important role in the pathogenesis and pathological changes of liver cancer,the analysis of its theoretical connotation helps to clarify pathological mechanism,thereby providing a theoretical basis for the role of TCM in the prevention and treatment of liver cancer.