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睡眠呼吸暂停低通气综合征患者泪膜功能变化的研究

Evaluation of tear film function in patients with sleep apnea hypopnea syndrome
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摘要 背景 睡眠呼吸暂停低通气综合征(sleep apnea hypopnea syndrome,SAHS)是一种常见的睡眠障碍,与多种眼部疾病有关。近年来,研究者逐渐重视SAHS与干眼症之间的关系。目的 利用Keratograph 5M眼表综合分析仪评价SAHS患者泪膜功能的变化。方法 纳入40例初次诊断SAHS患者和30例无眼干症状、无SAHS的志愿者。分别进行睡眠监测和Keratograph 5M眼表综合分析仪检查。结果 与对照组比较,SAHS组患者的首次泪膜破裂时间、平均泪膜破裂时间较短,中央泪河高度较低,上、下睑板腺缺失程度评分较高,但差异均无统计学意义(P>0.05)。中重度SAHS患者睑板腺缺失程度显著高于轻度SAHS患者(P<0.05);中重度缺氧患者泪膜破裂时间显著短于轻度缺氧患者(P<0.05),睑板腺缺失程度显著高于轻度患者(P<0.05),差异均有统计学意义。结论 阻塞程度越重、缺氧越严重的SAHS患者越容易出现睑板腺完整性的破坏,导致泪液分泌减少,泪膜破裂时间缩短。 Background Sleep apnea hypopnea syndrome(SAHS) is a common sleep disorder associated with a variety of eye diseases. In recent years, researchers have gradually paid attention to the relationship between SAHS and dry eye syndrome.Objective To evaluate the changes of tear film function in patients with SAHS by Keratograph 5M ocular surface comprehensive analyzer. Methods Forty patients who were diagnosed with OSAHS initially and 30 healthy volunteers were enrolled. Sleep monitoring and Keratograph 5M ocular surface comprehensive analysis were performed respectively. Results Compared with the control group, the first tear breakup time, average tear breakup time and central tear river height decreased in the SAHS group,while the scores of loss degree of upper and lower meibomian glands increased, but the differences were not statistically significant(P>0.05). With the increase of obstruction severity, there was obvious absence of meibomian gland(P<0.05). With the increasing degree of hypoxia, the time of tear film rupture was shortened and the meibomian gland loss increased(P<0.05).Conclusion Keratograph 5M ocular surface comprehensive analyzer can objectively and intuitively evaluate the tear film status of SAHS patients. The more severe obstruction and hypoxia is, the more meibomian gland integrity is destroyed, resulting in the decline of tear film function.
作者 毕晓达 赵娟 刘金伟 王倩 司艳芳 BI Xiaoda;ZHAO Juan;LIU Jinwei;WANG Qian;SI Yanfang(Department of Ophthalmology,the Eighth Medical Center,Affiliated to Senior Department of Ophthalmology,the Third Medical Center,Chinese PLA General Hospital,Beijing 100091,China;Department of Otolaryngology,the Eighth Medical Center,Chinese PLA General Hospital,Beijing 100091,China)
出处 《解放军医学院学报》 CAS 北大核心 2023年第1期28-32,共5页 Academic Journal of Chinese PLA Medical School
关键词 Keratograph 睡眠呼吸暂停低通气综合征 干眼 Keratograph sleep apnea hypopnea syndrome dry eye
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