两种麻醉药物对高龄患者临床效果的影响比较研究

A Comparative Study of the Effects of Two Kinds of Narcotic Drugs on the Clinical Outcomes of Elderly Patients

为分析不同药物麻醉对高龄患者麻醉效果的影响,选择2021年1月—2022年1月承德市中医院收治的100例高龄手术患者,将其随机分为观察组、对照组,分别给予依托咪酯乳状注射液麻醉、枸橼酸舒芬太尼注射液麻醉。观察组术后6h、术后48h的MMSE(简单智力状态检查量表)评分高于对照组(P<0.05)。观察组术后即刻、术后24h的肾上腺素水平、去甲肾上腺素水平、皮质醇水平均低于对照组(P<0.05)。观察组苏醒质量各指标均较对照组更短(P<0.05)。两组出院半年后的恢复情况无明显差异(P>0.05)。研究证明临床采用依托咪酯乳状注射液为高龄患者行麻醉药物诱导,更有利于改善其苏醒质量,提高术后认知功能,降低发生术后应激反应的风险。

In order to analyze the influence of different drug anesthesia on the anesthesia effect of elderly patients,100 elderly surgical patients admitted to Chengde Hospital of traditional Chinese medicine from January 2021 to January 2022 were randomly divided into observation group and control group,and were given etomidate emulsion injection anesthesia and sufentanil citrate injection anesthesia respectively.The MMSE(simple intelligence state examination scale)score of the observation group was higher than that of the control group at 6h and 48h after operation(P<0.05).The levels of epinephrine,norepinephrine and cortisol in the observation group immediately after operation and 24 hours after operation were lower than those in the control group(P<0.05).The recovery time of the observation group was shorter than that of the control group(P<0.05).There was no significant difference in recovery between the two groups half a year after discharge(P>0.05).The clinical use of etomidate emulsion injection for anesthesia induction in elderly patients is more conducive to improving their waking quality,improving their postoperative cognitive function,and reducing the risk of postoperative stress reaction.