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COVID-19相关性肌肉减少症发生机制及防治的研究进展 被引量:1

Research progress in pathogenesis,prevention and treatment of COVID-19 associated sarcopenia
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摘要 新型冠状病毒感染(COVID-19)已被世界卫生组织宣布为大流行病。研究发现,COVID-19幸存患者患急性肌肉减少症和潜在肌肉功能不全的风险增加。肌肉减少症(肌少症)是一种严重肌肉功能不全的病症,以骨骼肌质量和功能下降为特征,严重影响生活质量,且伴随不良后果风险增加。COVID-19可通过多种机制导致肌少症的发生,包括血管紧张素转化酶2(ACE2)缺失、炎症、长期卧床与体力活动减少、缺氧、食物摄入不足、糖皮质激素应用。COVID-19相关性肌少症的防治方法很多,包括加强运动、补充蛋白质及热量、补充长链ω-3脂肪酸和补充维生素D。 COVID-19 has been declared a pandemic by the World Health Organization.It has been found that among survivors of COVID-19,there is an increased risk of acute sarcopenia and potential muscle dysfunction.Sarcopenia is a serious muscle dysfunction disease,which is characterized by the decline of skeletal muscle quality and function.It seriously affects the quality of life and increases the risk of adverse consequences.COVID-19 can develop sarcopenia through a variety of mechanisms,including ACE2 deficiency,inflammation,long-term bed rest and physical activity reduction,hypoxia,insufficient food intake,glucocorticoid application.The prevention and treatment methods of COVID-19 related sarcopenia include strengthening exercise,supplementing protein and calories,supplementing long chainω-3 fatty acid and vitamin D.
作者 张文典 ZHANG Wendian(General Medicine Department of The First People's Hospital of Xiangtan City,Xiangtan 411101,China)
出处 《老年医学研究》 2023年第1期62-66,共5页 Geriatrics Research
关键词 新型冠状病毒感染 肌肉减少症 血管紧张素转化酶2 缺氧 维生素D COVID-19 sarcopenia angiotensin-converting enzyme 2 hypoxia vitamin D
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