摘要
动脉粥样硬化(Atherosclerosis, AS)是心血管疾病的病理基础。活性氧(Reactive oxygen species, ROS)与机体的各种生理过程相关,过高的ROS可以对血管相关的细胞造成损伤,影响其正常功能,并参与AS中血管的损伤和斑块生成。ROS介导的氧化应激参与AS的发生发展,通过调节机体内的抗氧化反应是预防和治疗AS的方向之一,而调节抗氧化相关的转录因子是主要的手段。文章主要从ROS及抗氧化相关转录因子对AS的影响进行综述。
Atherosclerosis(AS) was the pathological basis of cardiovascular disease.Reactive oxygen species(ROS) were related to various physiological processes in the body.Excessive ROS could be caused damage to vascular-related cells and affect their normal function, and could participate in blood vessel damage and plaque formation in AS.ROS-mediated oxidative stress was involved in the occurrence and development of AS,and it was one of the directions to prevent and treat AS by regulating the antioxidant response in the body.Regulating antioxidant-related transcription factors were the main means of antioxidation.The effects of ROS and antioxidation-related transcription factors on AS were summarized in this review.
作者
张通
何鑫
何书英
ZHANG Tong;HE Xin;HE Shu-ying(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)
出处
《药物生物技术》
CAS
2022年第6期653-656,共4页
Pharmaceutical Biotechnology
关键词
活性氧
动脉粥样硬化
核因子E2相关因子2
抗氧化
氧化应激
过氧化物酶体增殖物激活受体
Reactive oxygen species
Atherosclerosis
Nuclear factor E2-related factor 2
Antioxidant
Oxidative stress
Peroxisome proliferators-activated receptors
