铁死亡与中枢神经系统疾病的关联概述及中医药干预进展

Association Between Ferroptosis and Central Nervous System Diseases and A Review of Traditional Chinese Medicine Intervention

中枢神经系统(CNS)是一个受复杂调控的精密系统,主导人体高级神经活动。CNS结构的复杂性,调控机制的精密性,涵盖病种的多样性导致其成为诸多慢性病、疑难病、罕见病产生的高地。神经细胞是构成CNS的基本单位,其功能障碍与死亡是造成CNS疾病的根本原因。铁死亡是近年来提出的新型程序性细胞死亡形式,已被证实与多种CNS疾病的产生与进展密切相关。中医药形式多样,包含中药、针灸、推拿等多个组成部分,长久以来在CNS疾病治疗中显示出独特优势。已有大量研究论证中医药通过铁死亡途径参与CNS疾病的调节,显示出良好的研究前景。该文概述铁死亡的机制与调解途径,探讨铁死亡与CNS疾病的病理机制关联,总结中医干预方式通过铁死亡途径对多种CNS疾病的调控的现状与进展,为日后中医药更好的参与CNS疾病治疗提供参考。

Central nervous system(CNS) is a sophisticated system subject to complex regulation, which dominates the high-level neural activities of the human body. Due to its complex physiological structure and refined regulatory mechanism covering a variety of diseases, CNS is the place where many chronic, refractory and rare diseases occur. Nerve cell is the basic unit of CNS, and its dysfunction and death is the root cause of CNS diseases. Ferroptosis is a new form of programmed cell death proposed in recent years, and has been proved to be closely related to the production and development of multiple CNS diseases. Traditional Chinese medicine(TCM), including Chinese herbs, acupuncture and moxibustion, and massage, has shown unique advantages in the treatment of CNS diseases for a long time. A large number of studies have demonstrated that TCM participates in the regulation of CNS diseases via regulating ferroptosis and shows a good research prospect. This paper summarized the characteristics of ferroptosis and discussed the association between ferroptosis and CNS diseases in pathological mechanism. We also reviewed the regulation of various CNS diseases by different TCM interventions through ferroptosis, providing references for TCM to participate in the treatment of CNS diseases properly in the future.