基于外泌体miRNA靶向诊疗结直肠癌的研究进展

Research progress of targeted diagnosis and treatment of colorectal cancer based on exosomal miRNA

源于循环外泌体的miRNA可以从细胞代谢以及肿瘤微环境等方面调节结直肠癌的发生与发展。此外,外泌体miRNA还具有反映结直肠癌的分期、疗效、化疗耐药性以及复发风险的潜力。基于其生物学特征,本文系统梳理了外泌体miRNA作为结直肠癌诊断和预后生物标志物的相关研究,并阐明了基于miRNA靶向治疗结直肠癌的相关机制,旨在为外泌体miRNA成为结直肠癌的关键生物标志物和创新性治疗靶点提供理论基础。

MiRNA derived from circulating exosome regulate the development of colorectal cancer from both cell metabolism and tumor microenvironment aspects.In addition,exosomal miRNA has the potential to reflect the staging,therapeutic efficacy,chemotherapy resistance and recurrence risks of colorectal cancer.Based on its biological characteristics,we systematically reviewed that exosomal miRNA work as biomarkers for the diagnosis and prognosis of colorectal cancer,which were reported in related research,and we also summarized the mechanisms related to targeted treatment of colorectal cancer based on exsomal miRNA,in order to provide a theoretical basis for exosomal miRNA functioning as core biological markers and innovative therapeutic targets for colorectal cancer.