妊娠期高血压疾病患者维生素A、E水平与妊娠结局的关系

Relationship between vitamin A and E levels and pregnancy outcome in patients with gestational hypertension

目的探讨妊娠期高血压疾病患者维生素A、E水平与妊娠结局的关系。方法选择2018年3月至2021年4月江苏省苏州市中西医结合医院(以下简称“我院”)收治的82例妊娠期高血压疾病患者为研究组,另选取我院同期行常规体检的健康孕妇49名为对照组。比较对照组与研究组血清维生素A、E水平;研究组根据妊娠结局分为妊娠结局不良组和妊娠结局良好组,分析影响妊娠结局的因素。受试者操作特征曲线评估预测价值。结果研究组血清维生素A、E水平低于对照组,差异有统计学意义(P<0.05)。妊娠结局不良组与妊娠结局良好组孕前体重指数(BMI)、病情严重程度、24 h尿蛋白定量、血尿酸、白细胞介素-6、血清维生素A、血清维生素E比较,差异有统计学意义(P<0.05)。孕前BMI、病情严重程度、24 h尿蛋白定量、血清维生素A、血清维生素E为妊娠期高血压疾病患者不良妊娠结局的影响因素(P<0.05)。血清维生素A、E单独及联合预测妊娠期高血压疾病患者不良妊娠结局的曲线下面积分别为0.734、0.702、0.748。结论血清维生素A、E水平用于预测妊娠期高血压疾病患者不良妊娠结局具有重要价值。

Objective To investigate the relationship between vitamin A and E levels and pregnancy outcomes in patients with gestational hypertension.Methods A total of 82 patients with gestational hypertension admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu Province(“our hospital”for short)from March 2018 to April 2021 were selected as research group,in addition,49 healthy pregnant women who underwent routine physical examination during the same period in our hospital were selected as control group.The serum vitamin A and E levels of control group and research group were compared;the research group was divided into poor pregnancy outcome group and good pregnancy outcome group according to pregnancy outcomes,the factors affecting pregnancy outcome were analyzed.The predictive value was evaluated by receiver operating characteristic curve.Results Serum vitamin A,E levels in research group were lower than those in control group,and the differences were statistically significant(P<0.05).There were statistically significant differences in pre-pregnancy body mass index(BMI),disease severity,24 h urinary protein quantity,blood uric acid,interleukin-6,serum vitamin A,and serum vitamin E between poor pregnancy outcome group and good pregnancy outcome group(P<0.05).Pre-pregnancy BMI,disease severity,24 h urinary protein quantity,serum vitamin A,and serum vitamin E were the influencing factors of adverse pregnancy outcome in pregnancy-induced hypertension patients(P<0.05).The areas under the curve of serum vitamin A,E single and combined forecast were 0.734,0.702,and 0.748,respectively.Conclusion Vitamin A and E levels are of great value in predicting adverse pregnancy outcomes in patients with gestational hypertension.