基于国家专利数据库分析中药复方治疗非酒精性脂肪性肝病的用药规律

Analysis on the medication rules of traditional Chinese medicine compound prescriptions in the treatment of non-alcoholic fatty liver disease based on the national patent database

目的通过数据挖掘技术分析国家中药专利复方治疗非酒精性脂肪性肝病(NAFLD)的用药规律。方法检索中国知网专利数据库和中国国家知识产权局专利检索与分析系统中建库至2022年4月治疗NAFLD的中药复方,运用Microsoft Excel软件和中医传承计算平台(V3.0)进行用药频数统计、性味归经、关联规则和聚类分析。结果最终纳入处方93个,中药共计241味。高频药物包括丹参、山楂、泽泻、柴胡、白术等,功效排名前4的分别是补虚药(补气药为主)、利水渗湿药、活血化瘀药和清热药,四气以温、微寒、寒为主,五味以苦、甘和辛为主,主归肝、脾经。挖掘出高频药对9个,药物关联规则8条,聚类分析获得3类组方。结论中药专利复方治疗NAFLD以益气健脾为主,配以疏肝行气、清热活血、利湿化浊等方法。

Objective To analyze the medication rules of national traditional Chinese medicine patent compound prescriptions in the treatment of non-alcoholic fatty liver disease(NAFLD)by data mining technology.Methods The traditional Chinese medicine compound prescriptions in the treatment of NAFLD in CNKI patent database and the Patent Search and Analysis System of the State Intellectual Property Office of China from inception to April 2022 were searched.Microsoft Excel software and Traditional Chinese Medicine Inheritance Computing Platform(V3.0)were used for drug frequency statistics,nature,flavour,channel tropism,association rules,and cluster analysis.Results Finally,a total of 93 prescriptions were included,with 241 traditional Chinese medicine.High frequency drugs included Salviae Miltiorrhizae Radix Et Rhizoma,Crataegi Fructus,Alismatis Rhizoma,Bupleuri Radix,Atractylodis Macrocephalae Rhizoma,and so on.The top four efficacies were supplementing deficiency drugs(mainly supplementing qi drugs),diuresis and diffusing dampness drugs,promoting blood circulation for removing blood stasis drugs,and clearing heat drugs.The four nature of drugs were mainly warm,slightly cold,and cold,and the five flavours were bitter,sweet,and pungent,mainly returning to the liver and spleen channels.A total of nine high-frequency couplet medicines,eight drug association rules were discovered,and three types of prescriptions were obtained by cluster analysis.Conclusion The traditional Chinese medicine patent compound prescriptions in the treatment of NAFLD is based on the basic methods of invigorating qi and invigorating spleen,and apply the method of dispersing liver and promoting qi,clearing heat and activating blood,removing dampness and turbidification,and so on.