基于数据挖掘探析中医药治疗男性不育症的用药规律

Analysis on the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining

目的基于数据挖掘探析中医药治疗男性不育症的用药规律。方法收集并整理中国知网、维普网、万方数据库及中国生物医学文献数据库建库至2021年12月发表的关于中医药治疗男性不育症的经验方,在中医传承辅助平台(V2.5)中筛选并建立数据库,采用基本信息统计、频次分析、关联规则分析等相关数据挖掘技术,对医案进行分析并探究其用药规律、挖掘新方。结果共筛选出方剂114首,涉及单味中药160味。频次分析结果显示,菟丝子、枸杞子、熟地黄、淫羊藿、黄芪、山药、山茱萸、覆盆子、茯苓、当归居于用药频次前10位,药性以温、平为主;药味以甘味为主,辛、苦次之,归经以肾经、肝经为主;得出55条常用药物组合,11条药物关联规则以及7个潜在新方。结论中医药治疗男性不育症以补肾益精为基本治法,兼以活血化瘀,健脾利湿。

Objective To explore the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining.Methods The empirical prescriptions for male infertility treatment using traditional Chinese medicine published in China National Knowledge Infrastructure,VIP,Wanfang Data,Chinese Biomedical Literature databases from their inception to December 2021 were collected and sorted out.The database was screened and established on the Traditional Chinese Medicine Inheritance Assistant Platform(V2.5),and relevant data mining technologies such as basic information statistics,frequency analysis,and association rule analysis were used to analyze medical records,explore their medication rules,and explore new prescriptions.Results A total of 114 prescriptions were screened,involving 160 single traditional Chinese medicine.Frequency analysis results showed that Cuscutae Semen,Lycii Fructus,Rehmanniae Radix Praeparata,Epimedii Folium,Astragali Radix,Dioscoreae Rhizoma,Corni Fructus,Rubi Fructus,Poria,Angelicae Sinensis Radix ranked top ten in the frequency of drug use.The medicinal natures were mainly warm and plain.The main medicinal flavour was sweet,followed by pungent and bitter,and the channel tropism was mainly kidney and liver channels.A total of 55 common drugs combinations,11 drugs association rules,and seven potential new prescriptions were obtained.Conclusion The basic treatment of male infertility with traditional Chinese medicine is to tonify kidney and essence,and to promote blood circulation for removing blood stasis,invigorate spleen for promoting diuresis.