灸药结合对非小细胞肺癌气血亏虚型化疗后骨髓抑制的干预效果

Intervention effect of moxibustion combined with medicine on bone marrow suppression after chemotherapy in patients with non-small cell lung cancer of Qi and blood deficiency type

目的分析灸药结合对非小细胞肺癌气血亏虚型化疗后骨髓抑制的干预效果。方法2019年1月—2020年1月,选取100例在上海中医药大学附属岳阳中西医结合医院接受化疗的非小细胞肺癌气血亏虚型患者展开研究。随机(随机数表法)分为对照组和观察组各50例。对照组采用静脉滴注重组人粒细胞刺激因子注射液或输注血小板治疗,观察组给予灸药结合治疗。治疗10d后,分析比较两组治疗效果、血细胞计数、生活质量及不良反应。结果观察组的总有效率明显高于对照组(P<0.05);化疗后,两组的上述血细胞计数均降低,且观察组的白细胞、粒细胞、血红蛋白、血小板计数分别为(3.68±0.77)×10^(9)/L、(1.72±0.33)×10^(9)/L、(105.53±9.01)g/L、(130.23±16.11)×10^(9)/L,明显高于对照组的(2.91±0.61)×10^(9)/L、(1.34±0.41)×10^(9)/L、(102.11±8.08)g/L、(119.03±11.13)×10^(9)/L,差异有统计学意义(P<0.05);观察组的情绪功能、社会功能、躯体功能、角色功能、认知功能、总体健康评分分别为(62.55±11.43)分、(65.24±12.93)分、(74.86±10.22)分、(67.99±12.63)分、(73.13±12.36)分、(62.64±10.91)分,明显高于对照组的(58.32±9.95)分、(57.51±14.21)分、(58.34±10.62)分、(61.28±15.28)分、(68.33±8.34)分、(51.23±9.24)分,差异有统计学意义(P<0.05);观察组的总不良反应率为4.00%,明显低于对照组的16.00%,差异有统计学意义(P<0.05)。结论灸药结合对非小细胞肺癌气血亏虚型化疗后骨髓抑制的干预效果显著,可明显提高生活质量,降低不良反应发生率,在临床中值得推广应用。

Objective To analyze the intervention effect of moxibustion combined with medicine on bone marrow suppression after chemotherapy in patients with non-small cell lung cancer of Qi and blood deficiency type.Methods Totally 100 patients with non-small cell lung cancer of Qi and blood deficiency type who received chemotherapy in the Affiliated Yueyang Hospital of integrated traditional Chinese and Western Medicine of Shanghai University of traditional Chinese Medicine from January 2019 to January 2020 were selected as the research objects.They were randomly(random number table method)divided into control group and observation group with 50 cases in each.The control group was treated with intravenous infusion of recombinant human granulocyte stimulating factor injection or platelet transfusion,and the observation group was treated with moxibustion combined with medicine.After 10 days of treatment,the differences of therapeutic effect,blood cell count,quality of life and adverse reactions between the two groups were analyzed.Results The total effective rate of the observation group was significantly higher than the control group(P<0.05);after chemotherapy,the above blood cell counts of the two groups were decreased,and the white blood cell,granulocyte,hemoglobin and platelet counts of the observation group were(3.68±0.77)×10^(9)/L,(1.72±0.33)×10^(9)/L,(105.53±9.01)g/L,(130.23±16.11)×10^(9)/L,which were significantly higher than the control group(2.91±0.61)×10^(9)/L,(1.34±0.41)×10^(9)/L,(102.11±8.08)g/L,(119.03±11.13)×10^(9)/L,the difference was statistically significant(P<0.05);the scores of emotional function,social function,physical function,role function,cognitive function and overall health in the observation group were(62.55±11.43)scores,(65.24±12.93)scores,(74.86±10.22)scores,(67.99±12.63)scores,(73.13±12.36)scores,(62.64±10.91)scores,which were significantly higher than the control group(58.32±9.95)scores,(57.51±14.21)scores,(58.34±10.62)scores,(61.28±15.28)scores,(68.33±8.34)scores,(51.23±9.24)scores(P<0.05);the total adverse reaction rate of the observation group was 4.00%,which was significantly lower than 16.00% of the control group(P<0.05).Conclusion The intervention effect of moxibustion combined with medicine on bone marrow suppression after chemotherapy of Qi and blood deficiency type of non-small cell lung cancer is significant,which can significantly improve the quality of life,reduce the incidence of adverse reactions,and is worthy of promotion and application in clinical practice.