埃索美拉唑和奥美拉唑治疗胃溃疡的临床效果对比

Comparison of clinical efficacg of Esomeprazole and Omeprazole in the treatment of gastric ulcer

目的对比埃索美拉唑和奥美拉唑治疗胃溃疡的临床效果。方法选取十堰市郧阳区人民医院收治的胃溃疡患者82例(2019年6月-2020年6月),随机分为奥美拉唑治疗的对照组(41例)与埃索美拉唑治疗的观察组(41例),对比2组患者临床症状改善情况、血清炎性因子、恢复情况、不良反应发生率、治疗指标(止血时间、进食时间、住院时间)。结果观察组患者反酸、嗳气、腹胀、胃痛评分、血清IL-6、CRP水平、不良反应发生率均低于对照组(P<0.05)。观察组患者溃疡愈合时间、住院时间、止血时间、进食时间均短于对照组(P<0.05)。结论给予胃溃疡患者埃索美拉唑治疗,能促进临床症状改善,减轻炎症反应,促进溃疡面愈合,加快康复速度,且不良反应少。

Objective e To analyze the clinical effect and feasibility of esomeprazole and omeprazole in the treatment of gastric ulcer.Methods 82 patients with gastric ulcer in our hospital(June 2019 to June 2020)were randomly divided into omeprazole treatment control group(41 cases)and esomeprazole treatment observation group(41 cases).The improvement of clinical symptoms,serum inflammatory factors,recovery,incidence of adverse reactions and treatment indexes(hemostasis time,eating time and hospitalization time)were observed.ResultsThe levels of acid reflux,belching,abdominal distension,stomach pain score,IL-6,CRP and the incidence of adverse reactions in the observation group were lower than those in the control group(P<0.05);The ulcer healing time,hospital stay,hemostasis time,eating time in the observation group were shorter than those in the control group(P<0.05).ConclusionThe treatment of esomeprazole and omeprazole in patients with gastric ulcer can promote the improvement of clinical symptoms,reduce inflammatory reaction,promote the healing of ulcer surface,accelerate the speed of physical recovery,and have less adverse reactions.