摘要
Type 2 diabetes(T2D)has become a common chronic disease worldwide.Pancreaticβcell dysfunction,together with insulin resistance,is among the main causes for the pathogenesis of T2D.However,the dynamic changes in the number and function ofβcells and the molecular mechanism of irreversible damage in the pathogenesis of T2D are still unclear.A thorough analysis of the mechanism underlyingβcell dysfunction will provide a theoretical basis and molecular targets for the development of new and more effective individualized therapies for diabetes.
基金
This work was supported inpart by the National Natural Science Foundation of China(91857110,81722012,81670740,82070805,81870535,and 31870855)
the National Key Research and Development Programme of China(2018YFA0800403,2021YFC20701903,and 2020YFA0803704)
Zhejiang Provincial Natural Science Foundation of China(LZ21Ho70001)
the Construction Fund of Key Medical Disciplines of Hangzhou(0020200055)
the Innovative Instituteof Basic Medical Sciences of Zhejiang University
the Fundamental Research Funds for the Central Universities.
