Blood vessels in fat tissues and vasculature-derived signals in controlling lipid metabolism and metabolic disease

Metabolic disorders,including endocrine disorders,obesity,diabetes,cerebrocardiovascular disease,and even cancer,are the most common and lethal diseases with the leading all-cause mortality around the globe.[1]For example,according to the World Health Organization,type 2 diabetes mellitus(T2DM)as a chronic disease owing to insulin resistance became the ninth leading cause of death with 1.5 million deaths in 2019.[2]Currently,there are approximately 422 million people worldwide suffering from diabetes,with the majority living in low-and middle-income countries.[3]High T2DM prevalence has been associated with obesity and lifestyle factors such as lack of physical exercise,although genetic factors are linked to a subpopulation of T2DM patients.