阿奇霉素联合替考拉宁治疗门诊下呼吸道感染的效果

Effect of Azithromycin Combined with Teicoplanin in the Treatment of Outpatient Lower Respiratory Tract Infection

目的:观察阿奇霉素联合替考拉宁治疗门诊下呼吸道感染的效果及安全性。方法:选取郑州市第七人民医院2019年6月至2021年5月期间门诊的112例下呼吸道感染患者,按照随机数字表法分为对照组与观察组,各56例。对照组患者予以阿奇霉素治疗,观察组患者在对照组基础上加用替考拉宁治疗,比较两组患者临床效果、症状消失时间、治疗前后血清肿瘤坏死因子–α(TNF–α)、白细胞介素–6(IL–6)、超敏C反应蛋白(hs–CRP)水平、不良反应发生情况。结果:观察组患者总有效率为98.21%,高于对照组的78.57%,差异具有统计学意义(P <0.05);观察组患者咳嗽消失时间、发热消失时间、咯痰消失时间均短于对照组,差异具有统计学意义(P <0.05);观察组患者治疗后血清TNF–α、IL–6、hs–CRP水平均低于对照组,差异具有统计学意义(P <0.05);两组患者不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:阿奇霉素联合替考拉宁治疗门诊下呼吸道感染患者,可快速缓解患者临床症状,减轻炎症反应,安全性高。

Objective To observe the efficacy and safety of azithromycin combined with teicoplanin in the treatment of outpatient lower respiratory tract infection.Methods A total of 112 patients with lower respiratory tract infection in the Seventh People's Hospital of Zhengzhou from June 2019 to May 2021 were selected and divided into a control group and an observation group according to the random number table method,with 56 cases in each group.The control group was treated with azithromycin,and the observation group was treated with teicoplanin on the basis of the control group.The clinical effects,the disappearance time of symptoms,the levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 98.21%,higher than 78.57%of the control group,and the difference was statistically significant(P<0.05).The cough disappearance time,fever disappearance time and sputum disappearance time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of TNF-α,IL-6 and hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Azithromycin combined with teicoplanin in the treatment of outpatients with lower respiratory tract infection can quickly relieve the clinical symptoms of patients,reduce the inflammatory response,and has high safety.