养筋汤联合玻璃酸钠治疗肝肾亏虚型膝关节炎的临床研究

Clinical Study of Yangjin Decoction Combined with Sodium Hyaluronate in the Treatment of Knee Arthritis with Deficiency of Liver and Kidney

目的:观察养筋汤联合玻璃酸钠治疗肝肾亏虚型膝关节炎的临床疗效。方法:选取新里程安钢总医院2021年6月至2022年6月期间收治的86例原发性膝关节炎患者,采用随机对照法分为对照组和观察组,各43例。对照组患者予以玻璃酸钠注射液注射至膝关节腔,观察组患者在对照组基础上联用养筋汤。记录患者治疗前后疼痛,病情严重程度及影像学变化,评估临床疗效,记录治疗期间不良反应。结果:治疗后观察组患者视觉模拟评分法(VAS)评分低于对照组,差异具有统计学意义(P <0.05);治疗后观察组患者西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分低于对照组,差异具有统计学意义(P <0.05);治疗后观察组患者Kellgren分级分布优于对照组,差异具有统计学意义(Z=–4.241,P <0.05);观察组患者治疗总有效率为88.37%,高于对照组的72.09%,差异具有统计学意义(P <0.05);两组患者治疗期间均未出现明显不良反应,肝肾功能均未出现明显异常。结论:养筋汤联合玻璃酸钠治疗肝肾亏虚型膝关节炎近期疗效确切,可有效改善病情。

Objective To observe the clinical effect of Yangjin decoction combined with sodium hyaluronate in the treatment of knee arthritis with liver and kidney deficiency. Methods 86 patients with primary knee arthritis admitted to Xinlicheng Angang General Hospital from June 2021 to June 2022 were selected and divided into a control group and an observation group by randomized control method, with 43 cases in each group. The control group was given sodium hyaluronate injection into the knee cavity, and the observation group was given Yangjin decoction on the basis of the control group. Patients’ pain, severity and imaging changes before and after treatment were recorded, clinical efficacy was evaluated, and adverse reactions during treatment were recorded. Results After treatment, the visual analogue scale(VAS) score of the observation group was lower than that of the control group, and the difference was statistically significant(P < 0.05). After treatment, the score Western Ontario and McMaster University osteoarthritis index(WOMAC) in the observation group was lower than that in the control group, and the difference was statistically significant(P < 0.05). After treatment, Kellgren grading distribution in the observation group was better than that of the control group, and the difference was statistically significant(Z =-4.241, P < 0.05). The total effective rate of the observation group was 88.37 %, higher than 72.09 % of the control group, and the difference was statistically significant(P < 0.05). There were no obvious adverse reactions and no obvious abnormalities in liver and kidney function in the two groups during treatment.Conclusion Yangjin Decoction combined with sodium hyaluronate in the treatment of liver and kidney deficiency type knee arthritis has definite short-term effect and can effectively improve the condition.