基于芳基重氮盐的芳基自由基介导的不饱和键环化反应研究进展

Recent Progress in Aryl Radical-Mediated Cyclization of Unsaturated Bonds Based on Aryldiazonium Salts

芳基重氮盐以其较高的反应活性和广泛的来源,被广泛应用于有机合成中.芳基重氮盐作为一种常见的亲电试剂通过保留N_(2)骨架和离去N_(2),在材料化学、染料化学和药物化学等领域有着非常广泛的应用.近些年,随着自由基化学的迅速发展,利用芳基重氮盐产生芳基自由基参与的环化反应也得到了迅速的发展.整理了近十年来关于芳基重氮盐产生芳基自由基参与的环化反应的文献,从芳基自由基对不饱和碳碳键、碳氮键的加成后构建各种环状化合物进行归纳.最后,对目前的研究进展进行了总结.

Aryldiazonium salts are widely used in organic synthesis due to their high reactivity and readily availability.As a common arylation reagent,aryl diazonium salts have been widely used in material chemistry,dye chemistry and medicinal chemistry by retaining and leaving N_(2)skeleton.In recent years,with the rapid development of radical chemistry,the cyclization reaction involving aryl radicals,which produced by aryldiazonium salts,has also been developed rapidly,and this strategy also stimulates the enthusiasm of organic chemists to construct various ring compounds.In this review,the addition of unsaturated carbon-carbon bonds and carbon-nitrogen bonds to construct various cyclic compounds from aryl radicals is summarized and classified according to the size of the cyclic compounds.Finally,the current research progress is summarized.