全碳体系的5-endo-Trig自由基环化反应研究进展

Recent Advances on 5-endo-Trig Radical Cyclization of All-Carbon Systems

5-endo-trig自由基环化是快速构筑五元环的理想方法之一.Baldwin-Beckwith规则指出,受立体电子效应影响,5-endo-trig自由基环化通常是动力学不利的.近年来,化学工作者一直致力于探索促进5-endo-trig自由基环化的新策略,以期发展高效、高选择性的五元碳环或杂环化合物的合成方法.综述了4-戊烯基自由基5-endo环化的最新进展,总结归纳了主要的促进策略,希望推动5-endo-trig自由基环化反应的进一步设计和发展.

The 5-endo-trig radical closure has emerged as an ideal method for the fast aseembly of five-membered rings.It is believed to be kinetically disfavored due to the stereoelectronic disadvantages,so it is recognized as a disfavored process according to the Baldwin-Beckwith rules.Despite the challenges,continuous efforts have been devoted to develop effective strategies that enable 5-endo-trig radical cyclization.The recent advances on 5-endo-trig closure of 4-pentenyl radicals are summarized and the common strategies for accelerating the cyclization are analyzed,which will be valuable for the design and development of novel radical 5-endo-trig processes.