涉及未活化环烷烃C(sp^(3))—H官能化的自由基串联环化反应

Radical Cascade Cyclization Involving C(sp^(3))—H Functionalization of Unactivated Cycloalkanes

未活化环烷烃是最广泛的自然资源之一,发展温和、高效的未活化环烷烃C(sp^(3))—H官能化策略具有重要意义,同时,开发环状化合物的制备方法是有机合成和药物化学的研究热点.涉及未活化环烷烃C(sp^(3))—H官能化的自由基串联环化因具有反应条件温和、反应活性高等优势而能同时满足上述需求,以高原子和高步骤经济性的方式构建具有潜在应用价值的环状分子.从铁催化、铜催化以及无金属催化剂体系的角度出发,简要论述了近十年涉及未活化环烷烃C(sp^(3))—H官能化的自由基串联环化反应研究进展.

Unactivated cycloalkane is one of the most extensive natural resources,and it is of great significance to develop mild and efficient strategies to achieve C(sp^(3))—H of unactivated cycloalkanes.At the same time,the preparation of ring compounds is one of the hotspots in organic synthesis and medicinal chemistry.Because of the advantages of mild conditions and high reactivity,radical cascade cyclization involving C(sp^(3))—H functionalization of unactivated cycloalkanes can simultaneously meet the above requirements and synthesize cyclic molecules with potential applications in high atomic-and stepeconomy manner.In this review,from the point of view of iron catalysis,copper catalysis,and metal-catalyst-free systems,the advances in radical cascade cyclization involving C(sp^(3))—H functionalization of unactivated cycloalkanes in recent ten years are summarized.