Rh催化N-磺酰腙的偕-二氟烯丙基化反应

Rh-Catalyzed gem-Difluoroallylation of N-Tosylhydrazones

发展了一种铑催化N-磺酰腙和3,3-二氟烯丙基硫化物的重排反应合成偕-二氟烯丙基化合物的高效方法.该方法具有中等至优异的收率和良好的官能团耐受性,并通过两步一锅、克级合成和产物的衍生化验证了其实用性.

A rhodium-catalyzed rearrangement reaction of N-tosylhydrazones and 3,3-difluoroallyl sulfides was developed.This protocal provided a facile and efficient synthesis route to gem-difluoroallyl compounds with medium to excellent yield and good functional group tolerance.Moreover,the applicability of current method has been demonstrated by one-pot reaction,gram-scale synthesis and further transformations.