基于数据挖掘探讨中医药治疗腹泻型肠易激综合征用药规律

Discussion on Administration Rules of Traditional Chinese Medicine for Diarrhea Predominant Irritable Bowel Syndrome Based on Data Mining

目的:采用数据挖掘方法探讨中医药治疗腹泻型肠易激综合征(IBS-D)的组方用药规律。方法:检索1985—2020年中国知网(CNKI)有关中医药治疗IBS-D的临床研究。采用Microsoft Excel 2016建立中药处方信息表,利用SPSS20与SPSS Modeler 18软件进行频数、性味归经、关联规则、聚类分析等以挖掘中医药治疗IBS-D的用药规律。结果:共纳入文献366篇,中药处方417首,涉及中药205味。药物使用频次较高的中药有白术、甘草、白芍、茯苓、陈皮、防风等。治疗药物以补虚药、理气药为主;药味多见甘味,药性以温、平性为主,多归于脾、胃、肺经。治疗常用药对组合有白术-白芍、白术-白芍-茯苓、防风-白术-茯苓等。聚类分析得出5类处方,主要功效为调和肝脾、健脾祛湿、温阳止泻、补虚止泻等。结论:中医药治疗IBS-D主张整体观念和辨证论治,采用调和肝脾、健脾祛湿、温阳止泻等法治疗,临床常用痛泻要方、四神丸等加减方辨证治疗。

Objective:To discuss the administration rules of traditional Chinese medicine(TCM) for diarrhea predominant irritable bowel syndrome(IBS-D) by data mining.Methods:The clinical studies on TCM for IBS-D on the China Knowledge Network Infrastructure(CNKI) from 1985 to 2020 were retrieved.The information tables of Chinese herbal prescriptions were made by Microsoft Excel 2016,and the software,including SPSS20 and SPSS Modeler 18 were used to perform frequency analysis,nature flavor and channel tropism analysis,association rules analysis and cluster analysis,in order to dig out the administration rules of TCM for IBS-D.Results:A total of 366 documents were included,with 417 Chinese herbal prescriptions concerning 205 kinds of Chinese herbs.Such Chinese herbs as Atractylodis Macrocephalae Rhizoma,Radix Glycyrrhizae,Paeoniae Radix Alba,Poria,Citri Reticulatae Pericarpium and Saposhnikoviae Radix were used more frequently.They are mainly of deficiency-supplementing,qiregulating types;and most of them are sweet in flavor and warm and neutral in nature,with main meridian entries of the spleen meridian,the stomach meridian and the lung meridian.The medicinal combinations commonly used include Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba,Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba-Poria,and Saposhnikoviae Radix-Atractylodis Macrocephalae Rhizoma-Poria.Based on the cluster analysis,finally 6 types of descriptions were concluded,with main effects of harmonizing the liver and the spleen,fortifying the spleen and dispelling dampness,warming yang to check diarrhea,tonifying deficiency to check diarrhea.Conclusion:Committed to the holism and syndrome differentiation treatment,TCM treatment for IBS-D applys therapies of harmonizing the liver and the spleen,fortifying the spleen and dispelling dampness,and warming yang to check diarrhea,and modified formulas,including Important Formula for Painful Diarrhea and Four Spirits Pills,are given accordingly in clinical treatment.