通腑清浊舒心方加减联合盐酸地尔硫[艹卓]片治疗冠心病心绞痛临床研究

Clinical Study on Modified Tongfu Qingzhuo Shuxin Recipe Combined with Diltiazem Hydrochloride Tablets for Angina Pectoris of Coronary Heart Disease

目的:观察通腑清浊舒心方加减联合盐酸地尔硫[艹卓]片治疗冠心病心绞痛的临床疗效。方法:选取100例冠心病心绞痛患者,按随机数字表法分为对照组和观察组各50例。对照组采用盐酸地尔硫[艹卓]片治疗,观察组在对照组基础上给予通腑清浊舒心方加减治疗。评价2组临床疗效,比较2组治疗前后全身血管阻力(SVR)、血浆可溶性CD105(sCD105)、内皮素-1(ET-1)水平。结果:观察组总有效率为96.00%,高于对照组84.00%(P<0.05)。治疗前,2组SVR、sCD105、ET-1水平比较,差异无统计学意义(P>0.05)。治疗后,2组SVR、s CD105、ET-1水平较治疗前降低(P<0.05),且观察组SVR、sCD105、ET-1水平低于对照组(P<0.05)。结论:通腑清浊舒心方加减联合盐酸地尔硫[艹卓]片治疗冠心病心绞痛能有效改善患者的心血管功能,降低炎症反应,提高临床疗效。

Objective:To observe the clinical effect of the therapy of modified Tongfu Qingzhuo Shuxin Recipe combined with Diltiazem Hydrochloride Tablets on angina pectoris of coronary heart disease.Methods:A total of 100 cases of angina pectoris of coronary heart disease were selected and divided into the control group and the observation group according to random number table method,with 50 cases in each group. The control group was treated with Diltiazem Hydrochloride Tablets,and the observation group was additionally treated with modified Tongfu Qingzhuo Shuxin Recipe. The clinical effects in the two groups were evaluated,and the levels of systemic vascular resistance(SVR),plasma soluble CD105(sCD105) and endothelin-1(ET-1) were compared between the two groups before and after treatment. Results:The total effective rate was 96.00% in the observation group,higher than that of 84.00% in the control group(P<0.05). Before treatment,there was no significant difference in the levels of SVR,sCD105 and ET-1between the two groups(P>0.05). After treatment, the levels of SVR, s CD105 and ET-1 in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of SVR,sCD105 and ET-1 in the observation group were lower than those in the control group(P<0.05).Conclusion: The therapy of modified Tongfu Qingzhuo Shuxin Recipe combined with Diltiazem Hydrochloride Tablets can effectively improve the cardiovascular function of patients with angina pectoris of coronary heart disease,reduce inflammation and enhance clinical effect.