坤泰胶囊与芬吗通联合治疗对更年期综合症患者性激素水平、睡眠状况的影响

Effect of Kuntai Capsules Combined with Femoston on Sex Hormone Levels and Sleep Status of Patients with Menopausal Syndrome

目的:观察坤泰胶囊与芬吗通联合治疗更年期综合征(CS)的临床疗效。方法:将90例CS患者随机分为常规组与研究组各45例,常规组给予芬吗通治疗,研究组给予芬吗通与坤泰胶囊联合治疗。比较2组治疗前后性激素水平、改良Kupperman评分、睡眠情况及治疗后临床疗效。结果:治疗前,2组卵泡刺激素(FSH)、雌二醇(E_(2))、促黄体生成激素(LH)水平比较,差异无统计学意义(P>0.05);治疗后,2组FSH、LH水平均降低(P<0.05),E_(2)水平均升高(P<0.05),且研究组FSH、LH水平低于常规组(P<0.05),E_(2)水平高于常规组(P<0.05)。治疗前,2组睡眠时间、入睡时间比较,差异无统计学意义(P>0.05);治疗后,2组睡眠时间延长(P<0.05),入睡时间缩短(P<0.05),且研究组睡眠时间长于常规组(P<0.05),入睡时间短于常规组(P<0.05)。治疗前,2组改良Kupperman评分比较,差异无统计学意义(P>0.05);治疗后2组改良Kupperman评分均降低(P<0.05),且研究组低于常规组(P<0.05)。治疗后,研究组治疗总有效率88.89%,高于常规组71.11%(P<0.05)。治疗期间2组均未出现明显不良反应。结论:坤泰胶囊与芬吗通联合治疗女性CS可调节性激素分泌,改善患者临床症状,疗效安全、可靠。

Objective:To observe the clinical effect of Kuntai Capsules combined with Femoston for menopause syndrome(CS).Methods:A total of 90 cases of CS patients were randomly divided into the routine group and the study group,with 45 cases in each group.The routine group was treated with Femoston,and the study group was treated with Femoston combined with Kuntai Capsules.Sex hormone levels,modified Kupperman scores and sleep status before and after treatment as well as clinical effects after treatment were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of the levels of follicle-stimulating hormones(FSH),estradiol(E_(2))and luteinizing hormone(LH)between the two groups(P>0.05);after treatment,the levels of FSH and LH in the two groups were decreased(P<0.05),and the levels of E_(2) were increased(P<0.05);the levels of FSH and LH in the study group were lower than those in the routine group(P<0.05),and the level of E_(2) was higher than that in the routine group(P<0.05).Before treatment,there was no significant difference being found in the comparison of sleep time and time for falling asleep between the two groups(P>0.05);after treatment,the sleep time in the two groups was prolonged and the time for falling asleep was shortened(P<0.05);the sleep time in the study group was longer than that in the routine group(P<0.05),and the time for falling asleep was shorter than that in the routine group(P<0.05).Before treatment,there was no significant difference being found in the comparison of modified Kupperman scores between the two groups(P>0.05);after treatment,modified Kupperman scores in the two groups were decreased(P<0.05),and the score in the study group was lower than that in the routine group(P<0.05).After treatment,the total effective rate was 88.89%in the study group,higher than that of 71.11%in the routine group(P<0.05).During the treatment,there were no obvious adverse reactions in the two groups.Conclusion:Kuntai Capsules combined with Femoston for CS in female can regulate the secretion of sex hormones and improve the clinical symptoms of patients,with a safe and reliable curative effect.