免疫三氧辅助疗法联合西药治疗系统性红斑狼疮临床研究

Clinical Study on Ozone Therapy Combined with Western Medicine for Systemic Lupus Erythematosus

目的:观察免疫三氧辅助疗法联合西药治疗系统性红斑狼疮(SLE)的临床疗效。方法:选取50例SLE患者,按随机数字表法分为试验组20例及对照组30例,其中试验组脱落2例,对照组脱落4例。对照组采用西药治疗,试验组采用免疫三氧辅助疗法联合西药治疗,2组治疗周期为4周,随访时间为治疗结束当天及治疗后2个月。比较2组治疗前后疾病活动度(SLEDAI)评分、胃肠道症状分级评分、补体C3、补体C4值及健康状况评价量表(SF-36)评分的变化,观察2组治疗期间不良反应发生情况。结果:治疗4周后,2组SLEDAI评分均较治疗前下降(P<0.05),2组SLEDAI评分比较,差异无统计学意义(P>0.05)。治疗4周后及随访2个月,2组SF-36评分均较治疗前提高(P<0.05),试验组SF-36评分均高于同一时间段对照组(P<0.05)。治疗4周后、随访2个月,2组胃肠道症状分级评分均较治疗前下降(P<0.05),试验组胃肠道症状分级评分低于同一时间段对照组,但差异无统计学意义(P>0.05)。治疗4周后,2组补体C3、补体C4值均较治疗前上升,但差异无统计学意义(P>0.05);2组组间比较,差异无统计学意义(P>0.05)。本试验过程中2组均无不良反应出现。结论:免疫三氧辅助疗法联合西药治疗SLE效果较好,可促进体内氧气供给,增强机体免疫力,改善患者生活质量。

Objective:To observe the clinical effect of ozone therapy combined with western medicine for systemic lupus erythematosus(SLE). Methods:A total of 50 cases of SLE patients were selected and divided into the trial group and the control group according to the random number table method, with20 and 30 cases in each group respectively;two cases dropped out in the trial group,and 4 cases in the control group. The control group was treated with western medicine,and the trial group was treated with ozone therapy combined with western medicine. Both groups were treated for 4 weeks,and the follow-up was carried out at the day of the end of treatment,and 2 months after treatment. The changes in Systemic Lupus Erythematosus Disease Activity Index(SLEDAI) scores, gastrointestinal symptom grading scores,values of complement C3 and complement C4,and Health Status Questionnaire(SF-36) scores before and after treatment were compared between the two groups. The incidence of adverse reactions during treatment was observed between the two groups. Results:After 4-week treatment,SLEDAI scores in the two groups were decreased when compared with those before treatment(P<0.05);there was no significant difference being found in the comparison of SLEDAI scores between the two groups(P>0.05).After 4-week treatment and during the 2-month follow-up, SF-36 scores in the two groups were increased when compared with those before treatment(P<0.05),and the SF-36 scores in the trial group were higher than those in the control group in the same period(P<0.05). After 4-week treatment and2-month follow-up,the gastrointestinal symptom grading scores in the two groups were decreased when compared with those before treatment(P<0.05),and the gastrointestinal symptom grading scores in the trial group were lower than those in the control group in the same period,there being no significance in the difference(P>0.05). After 4-week treatment,the values of complement C3 and complement C4 in the two groups were increased when compared with those before treatment,there being no significance in the difference(P>0.05);no significant difference being found in the comparison of the values of complement C3 and complement C4 between the two groups(P>0.05). There was no adverse reaction during the trial in the two groups. Conclusion:Ozone therapy combined with western medicine has a good effect in treating SLE, and can promote the oxygen supply in the body, enhance the body immunity, and improve the quality of life of patients.