唾液富组蛋白5——治疗白念珠菌感染的一种新策略

Salivary histatin 5:a new strategy for the treatment of Candida albicans infection

白念珠菌是一种机会性病原体,可引起不同部位的真菌感染。目前,白念珠菌治疗药物单一,且随着临床药物的不合理使用,白念珠菌耐药问题日益加剧。富组蛋白5(Hst-5)是口腔唾液中分泌最丰富的抗菌肽,作为宿主第一道防御线,对白念珠菌具有很强的抗菌活性。其作用机制与传统抗真菌药物和其他抗菌肽不同,其中涉及白念珠菌表面的多种转运蛋白、MAPK途径、体外多种金属离子等,且随着对Hst-5的深入研究,发现Hst-5的多种衍生肽(K11R-K17R、P-113Tri等),在抗菌效力上能发挥更大杀伤力。因此,对Hst-5及其衍生肽在白念珠菌中的抗菌机制进行研究尤为重要,将为目前临床治疗真菌感染提供新策略。

Candida albicans(C. albicans) is an opportunistic pathogen that can cause fungal infection at different sites. At present, drugs for the treatment of C. albicans is single. With the irrational use of clinical drugs, drug resistance of C. albicans is becoming increasingly serious. Histatins 5(Hst-5) is the most abundant antimicrobial peptide(AMP) secreted from oral saliva. As the first defense line of the host, it has strong antibacterial activity against C. albicans. Its mechanism of action is different from that of traditional antifungal drugs and other antimicrobial peptides, which involves a variety of transport proteins on the surface of C. albicans, MAPK pathway, and various metal ions in vitro. With the in-depth study of Hst-5, it is found that a variety of derivative peptides of Hst-5(K11R-K17R, P-113Tri, etc.) can play a more vital role in improving antimicrobial efficacy. Therefore, it is particularly important to study the antimicrobial mechanism of Hst-5 and its derived peptides in C. albicans, which will provide a new strategy for the therapy of clinical fungal infections at present.