代谢综合征及其组分对慢性乙型肝炎患者血清HBsAg水平的影响

Effects of metabolic syndrome and its components on serum HBsAg levels in patients with chronic hepatitis B

目的探讨代谢综合征及其组分对慢性乙型肝炎患者血清HBsAg水平的影响,为慢性乙型肝炎合并代谢综合征患者后续的慢性乙型肝炎临床治愈提供思路。方法选取2020年5月至2021年9月在山西白求恩医院感染病科确诊初治的415例患者进行回顾性分析。根据是否合并代谢综合征将其分为慢性乙型肝炎组(CHB组),慢性乙型肝炎合并代谢综合征组(CHB合并MetS组)。收集患者的一般资料、生化指标、病毒学指标及肝脏瞬时弹性检查结果,通过非参数秩和检验、χ^(2)检验及多元线性回归等分析代谢综合征及其组分对慢性乙型肝炎患者血清HBsAg水平的影响。结果CHB组247例(59.50%),CHB合并MetS组168例(40.50%)。多元线性回归结果显示:血糖及甘油三酯对血清HBsAg水平的影响有统计学意义(t=-3.25,P=0.001;t=2.25,P=0.025),血压及腰围对血清HBsAg水平的影响差异无统计学意义。结论血糖负向预测慢性乙型肝炎患者血清HBsAg水平,甘油三酯正向预测慢性乙型肝炎患者血清HBsAg水平,而血压及腰围并不影响患者HBsAg水平。

Objective To explore the effects of metabolic syndrome and its components on serum HBsAg levels in patients with chronic hepatitis B,so as to provide ideas for the subsequent clinical cure of chronic hepatitis B patients with metabolic syndrome.Method A retrospective analysis of 415 patients with chronic hepatitis B who were admitted to Shanxi Bethune Hospital from May 2019 to September 2020.They were divided into chronic hepatitis B group and chronic hepatitis B combined with metabolic syndrome group according to whether they were complicated with metabolic syndrome.The general data,biochemical parameters,virological parameters,and liver transient elasticity were collected.Non-parametric rank sum test,chi-square test and multiple linear regression were used to analyze the effects of metabolic syndrome and its components on serum HBsAg levels in patients with chronic hepatitis B.Result A total of 415 patients were included in this study,including 247 patients(59.50%)in CHB group and 168 patients(40.50%)in CHB combined with MetS group.The results of multiple linear regression showed that blood glucose and triglyceride had statistically significant effects on serum HBsAg level(t=-3.25,P=0.001;t=2.25,P=0.025),while blood pressure and waist circumference had no statistically significant effects on serum HBsAg level.Conclusion Blood glucose negatively predicted serum HBsAg level in CHB patients,triglyceride positively predicted serum HBsAg level in CHB patients,but blood pressure and waist circumference did not affect the level of HBsAg.