血尿酸肌酐比及血脂代谢与男性慢性阻塞性肺疾病急性加重期患者气流受限程度关系的研究

Study on the Relationship between Serum Uric Acid to Creatinine Ratio and Lipid Metabolism and the Degree of Airflow Limitation in Male Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:通过对不同严重程度慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者血尿酸(urine acid,UA)肌酐(creatinine,Cr)比(UA/Cr)及血脂代谢水平的检测,探讨男性AECOPD患者UA/Cr及血脂的表达特征及其与气流受限程度的相关性。方法:选取2017年1月—2020年10月在中山大学附属第一医院呼吸科住院的222例AECOPD男性患者作为研究对象,以及同期住院的44例男性非慢性气道疾病患者,收集相关的临床资料、肾功能、血脂及肺功能检查指标,并进行分析。结果:患者UA/Cr与FEV_(1)、BMI存在相关性,相关系数r分别为-0.325、0.162。肺功能越差,体重指数越高,UA/Cr升高越明显。而UA/Cr与年龄、吸烟史未见明显相关性。此外,高密度脂蛋白胆固醇与FEV_(1)也存在明显相关性(r=-0.231)。结论:UA/Cr及高密度脂蛋白胆固醇可在一定程度上反映男性AECOPD患者气流受限程度。

Objective:To investigate the expression characteristics of UA/Cr and lipids and their correlation with the degree of airflow limitation in male patients with AECOPD by measuring urine acid(UA) creatinine(Cr) ratio(UA/Cr) and lipid metabolism levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) of different severity.Methods:A total of 222 male patients with AECOPD hospitalized from January 2017 to October 2020,as well as 44 male patients with non-chronic airway disease hospitalized during the same period,were selected and relevant clinical data were collected,and renal function,lipid and pulmonary function tests were analyzed.Results:There was a correlation between UA/Cr and FEV_(1) and BMI in patients,with correlation coefficients r of-0.325 and 0.162.The poorer the lung function and the higher the body mass index,the more pronounced the increase in UA/Cr.No significant correlation was seen between UA/Cr and age and smoking history.In addition,there was a significant correlation between HDL cholesterol and FEV_(1)(r=-0.231).Conclusion:UA/Cr and HDL cholesterol may reflect to some extent the degree of airflow limitation in men with AECOPD.