依托考昔致高血压亚急症1例

A case of hypertensive subemergency caused by etoricoxib

1例67岁男性患者,既往无高血压病史,因可疑痛风发作自2021年4月29日起口服依托考昔片(60 mg,qd)、碳酸氢钠片(1 g,tid),外用双氯芬酸钠二乙胺乳胶剂治疗。5月2日患者出现头晕,伴胸闷,自测血压180/90 mm Hg,服用苯磺酸氨氯地平片2.5 mg后复测收缩压降至150 mm Hg,头晕、胸闷等症状较前改善。5月3日患者晨起再次出现头晕发作,自测血压204/101 mm Hg,就诊于急诊予以对症降压治疗后好转,嘱停用依托考昔片。5月4–7日患者血压波动于130~150/70~80 mm Hg,头晕间断发作,未服药治疗。5月8日患者晨起后再次出现头晕发作,自测血压190/90 mm Hg,加服苯磺酸氨氯地平片5 mg后就诊于心内科。入院经各项检查排除原发疾病影响,未予降压治疗,1 d后患者血压恢复正常,准予出院。

A 67-year-old male patient with no previous history of hypertension received etoricoxib tablets(60 mg,qd),sodium bicarbonate tablets(1 g,tid)and external diclofenac diethylamine latex since April 29th,2021 due to a suspected gout attack.He developed dizziness and chest tightness with a self-measured blood pressure of 180/90 mm Hg on May 2nd.After taking amlodipine besylate tablets 2.5 mg,the systolic blood pressure dropped to 150 mm Hg accompanied by the relief of dizziness and chest tightness.On May 3th,he suffered from dizziness again in the morning with a self-measured blood pressure of 204/101 mm Hg.After seeing a doctor in the emergency department,he was relieved after symptomatic antihypertensive treatment and ordered to stop etoricoxib.From May 4thto May 7th,he developed intermittent dizziness without medication and his blood pressure fluctuated between 130-150/70-80 mm Hg.On May 8th,he developed dizziness again in the morning with a self-measured blood pressure of190/90 mm Hg.After taking amlodipine besylate tablets 5 mg,he went to the cardiology department.After admission,the influence of primary diseases was excluded through various examinations,and no antihypertensive treatment was given.One day later,the patient’s blood pressure returned to normal and he was discharged.