托烷司琼对无痛胃肠镜诊疗后患者认知功能的影响

Effect of tropisetron on cognitive function of patients after painless gastroenteroscopy

目的探讨托烷司琼应用于无痛胃肠镜对患者诊疗后认知功能的影响。方法选取2021年12月至2022年2月山东中医药大学附属医院接诊的160例无痛胃肠镜患者为研究对象,采用随机数字表法将其分为观察组和对照组,每组80例。应用丙泊酚麻醉并行无痛胃肠镜诊疗,在一般麻醉方案基础上,观察组应用盐酸托烷司琼注射液,对照组使用甲磺酸多拉司琼注射液。对比两组诊疗后认知功能[简易智力状态评估量表(Mini-Cog)评分]、认知受损筛查阳性率、不良反应发生情况及满意度。结果诊疗后观察组Mini-Cog评分高于对照组[(4.01±0.78)分vs.(3.62±0.87)分],差异有统计学意义(P<0.05)。诊疗后两组认知受损筛查阳性率和不良反应发生率比较,差异无统计学意义(P>0.05)。诊疗后观察组满意度高于对照组[4(3,5)分vs.4(3,4)分],差异有统计学意义(P<0.05)。结论托烷司琼可降低无痛胃肠镜对认知功能的不良影响。

Objective To investigate the effect of tropisetron on cognitive function of patients after diagnosis and treatment by painless gastroenteroscopy.Methods A total of 160 patients underwent painless gastroenteroscopy admitted to the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from December 2021 to February 2022 were selected and divided into the observation group and the control group by random number table method,with 80 patients in each group.Anesthesia with propofol and painless gastroenteroscopy were performed.Based on the general anesthesia regimen,tropisetron hydrochloride injection was used in the observation group,and dolasetron mesylate injection was used in the control group.After diagnosis and treatment,cognitive function[summary mental state assessment scale(Mini-Cog)score],positive rate of cognitive impairment screening,occurrence of adverse reactions and satisfaction were compared between the two groups.Results After diagnosis and treatment,the Mini-Cog score of the observation group was higher than that of the control group[(4.01±0.78)point vs.(3.62±0.87)point],the difference was statistically significant(P<0.05).There was no significant difference in the positive rate of cognitive impairment screening and the incidence of adverse reactions between the two groups after diagnosis and treatment(P>0.05).After treatment,the satisfaction of the observation group was higher than that of the control group[4(3,5)point vs.4(3,4)point],and the difference was statistically significant(P<0.05).Conclusion The use of tropisetron can reduce the adverse effects of painless gastroenteroscopy on cognitive function.