改良根治术联合自体植皮术治疗乳腺癌的临床疗效及术后早期预后的影响

Clinical Efficacy of Modified Radical Mastectomy Combined With Autologous Skin Grafting in the Treatment of Breast Cancer and the Influence of Early Postoperative Prognosis

目的 分析自体植皮术与改良根治术联合使用,对乳腺癌患者的临床疗效及对术后早期预后的影响。方法 选取94例乳腺癌患者,采用简单随机法分为观察组(n=47)与对照组(n=47)。对照组采取改良根治术进行治疗,观察组加以自体植皮术联合治疗,比较两组手术指标、皮瓣坏死、并发症发生率及1年内复发率。结果 与对照组相比,观察组手术耗时明显更长,术中出血量也明显更多,但住院时间则明显更短(P<0.05),两组术后引流时间差别较小(P>0.05)。观察组皮瓣坏死、并发症总发生率及复发率均相比对照组均明显更低(P<0.05)。结论 将改良根治术与自体植皮术联合用于乳腺癌患者的治疗中,能显著缩短其住院时间,同时使术后并发症的发生概率及复发率降低,但会使手术耗时更长、术中出血量变多,建议临床结合实际情况合理应用。

Objective To analyze the clinical effect of autologous skin grafting combined with modified radical mastectomy on patients with breast cancer and its influence on early postoperative prognosis.Methods 94 patients with breast cancer were randomly divided into observation group(n=47)and control group(n=47).The control group was treated with modified radical operation,Group A was treated with autologous skin grafting,and the operation indexes,skin flap necrosis,incidence of complications and recurrence rate within one year were compared between the two groups.Results Compared with the control group,the operation time of the observation group was significantly longer,the amount of blood loss during operation was significantly more,but the hospitalization time was significantly shorter(P0.05).The total incidence of skin flap necrosis,complications and recurrence rate in observation group were significantly lower than those in control group(P <0.05).Conclusion The combined application of modified radical mastectomy and autologous skin grafting in the treatment of breast cancer patients can significantly shorten the hospitalization time,and at the same time reduce the probability and recurrence rate of postoperative complications,but it will take longer operation time and increase the amount of bleeding during operation.It is suggested that clinical application should be reasonable according to the actual situation.