氯吡格雷联合阿托伐他汀钙治疗脑梗死患者的临床效果分析

Clinical Effect Analysis of Clopidogrel Combined with Atorvastatin Calcium in the Treatment of Cerebral Infarction Patients

目的:分析氯吡格雷联合阿托伐他汀钙治疗脑梗死患者的临床效果。方法:选取2021年1月-2022年1月山东省巨野县人民医院及四川省成都市第三人民医院门诊收治的脑梗死患者86例为观察对象,根据随机数字表法分为对照组、观察组,各43例。对照组给予氯吡格雷治疗,观察组给予氯吡格雷联合阿托伐他汀治疗,比较两组患者临床疗效、血脂指标[总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]及不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组TC、HDL-C、TG、LDL-C水平低于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未出现明显的不良反应。结论:氯吡格雷联合阿托伐他汀钙治疗脑梗死患者的临床效果显著,可以提高临床疗效,明显改善患者血脂水平,用药并不增加不良反应,安全性较高。

Objective:To analyze the clinical effect of clopidogrel combined with atorvastatin calcium in the treatment of cerebral infarction patients.Methods:A total of eighty-six cerebral infarction patients admitted to the department of outpatient of Juye County People's Hospital and Chengdu Third People's Hospital from January 2021 to January 2022 were selected as the observation objects,and were divided into control group and observation group according to random number table method,with forty-six cases in each group.The control group was treated with clopidogrel,and the observation group was treated with clopidogrel combined with atorvastatin.The clinical efficacy,blood lipid indexes[total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)]and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of TC,HDL-C,TG and LDL-C in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no obvious adverse reaction in the two groups during treatment.Conclusion:Clopidogrel combined with atorvastatin calcium has a significant clinical effect in the treatment of cerebral infarction patients,which can improve the clinical efficacy and significantly improve the blood lipid level of patients,and the drug does not increase adverse reactions,with high safety.