少腹逐瘀汤联合西药治疗对子宫内膜异位症患者临床疗效及其子宫内膜受容性的影响

Clinical effect of Shaofu Zhuyu Decoction combined with western medicine on patients with endometriosis and the influence of endometrial capacitance

目的:探讨少腹逐瘀汤联合西药治疗对子宫内膜异位症患者临床疗效及其子宫内膜受容性的影响研究。方法:选取84例子宫内膜异位症患者为研究对象,按照治疗方案不同分为对照组和观察组,每组各42例。对照组采用西药治疗;观察组在对照组西药基础上联合少腹逐瘀汤治疗,两组均治疗至出院后3个月。评估两组的临床疗效以及1年复发率,比较两组的中医证候评分、氧化应激状态与子宫内膜受容性参数。结果:观察组的总有效率高于对照组,1年复发率低于对照组(均P<0.05)。治疗后,观察组的中医证候评分、晚期蛋白氧化产物(AOPP)水平、丙二醛(MDA)水平、子宫动脉阻力指数均低于对照组(P<0.05);超氧化物歧化酶(SOD)水平、子宫内膜容积、子宫内膜厚度均高于对照组(P<0.05)。结论:少腹逐瘀汤联合西药治疗对子宫内膜异位症患者具有良好的临床疗效,可改善患者的中医证候评分以及子宫内膜受容性,优化氧化应激状态,降低复发率。

Objective:To investigate the clinical effect of Shaofu Zhuyu Decoction combined with western medicine on patients with endometriosis and its influence on endometrial receptivity.Methods:84 patients with endometriosis were selected as the research objects.According to the treatment plan, they were divided into the control group and the observation group, with 42 cases in each group.The control group was treated with western medicine.The observation group was treated with Shaofu Zhuyu Decoction based on the western medicine of the control group.Both groups were treated until 3 months after discharge.The clinical efficacy and 1-year recurrence rate of the two groups were evaluated, and the TCM syndrome score, oxidative stress state and endometrial receptivity parameters of the two groups were compared.Results: The total effective rate in the observation group were higher than that in the control group, and 1-year recurrence rate was lower than that in the control group(all P<0.05).After treatment, the scores of TCM syndromes, the levels of advanced protein oxidation products(AOPP),malondialdehyde(MDA) and uterine artery resistance index in the observation group were lower than those in the control group(P<0.05).The level of superoxide dismutase(SOD),endometrial volume and thickness in the observation group were higher than those in the control group(P<0.05).Conclusion:Shaofu Zhuyu Decoction combined with western medicine has a good clinical effect on patients with endometriosis, which can improve the score of TCM syndromes and endometrial receptivity, optimize the oxidative stress state, and reduce the recurrence rate.