胃癌根治术患者外周血CEA、AFP、PG Ⅰ的表达及与术后复发率的关系

Expressions of peripheral blood CEA,AFP and PG Ⅰ in patients undergoing radical resection of gastric cancer and their relationship with postoperative recurrence rate

目的:探讨胃癌根治术患者外周血癌胚抗原(CEA)、甲胎蛋白(AFP)、胃蛋白酶原Ⅰ(PGⅠ)的表达及与术后复发率的关系。方法:选取104例行胃癌根治术的患者为研究对象,根据否复发分为复发组(n=44)和未复发组(n=60)。比较两组患者病理特征及外周血CEA、AFP、PGⅠ水平;多因素Logistic回归分析影响术后复发的危险因素;受试者工作特征(ROC)曲线评估外周血指标对患者术后复发的诊断价值。结果:复发组分化程度、外周血PGⅠ水平低于未复发组(P<0.05);浸润深度及外周血CEA、AFP水平高于未复发组(P<0.05)。回归分析显示,外周血CEA、AFP、PGⅠ水平与术后复发相关(P<0.05)。ROC曲线分析显示,外周血CEA、AFP、PGⅠ水平可有效诊断术后复发(P<0.05)。结论:外周血CEA、AFP、PGⅠ的异常表达与胃癌根治术术后复发密切相关,对术后复发有诊断价值。

Objective:To analyze the relationship between expressions of peripheral blood carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP) and pepsinogen I(PG I) in patients undergoing radical resection of gastric cancer and their relationship with postoperative recurrence rate.Methods:A total of 104 patients undergoing radical resection of gastric cancer in the hospital were selected.Patients were divided into recurrence group(n=44) and non-recurrence group(n=60) according to recurrence.The pathological characteristics and levels of CEA,AFP and PG I in peripheral blood were compared between the two groups.Multivariate Logistic regression analysis was applied to analyze the risk factors affecting the postoperative recurrence, and receiver operating characteristic(ROC) curve was drawn to evaluate the diagnostic value of the above peripheral blood indicators on postoperative recurrence.Results:The degree of differentiation and the level of PGI in recurrence group were lower than those in non-recurrence group, and the depth of invasion and the levels of CEA and AFP were higher than those in non-recurrence group(P<0.05).Logistic regression analysis revealed that the levels of CEA,AFP and PG I in peripheral blood were correlated with postoperative recurrence, and ROC curve showed that the above indicators could effectively diagnose postoperative recurrence(P<0.05).Conclusion:The abnormal expressions of CEA,AFP and PG I in peripheral blood are closely related to postoperative recurrence of radical resection of gastric cancer, which has diagnostic value for the recurrence after operation.