口腔扁平苔藓女性患者血清25-羟维生素D3水平分析

The serum 25-(OH)D3 level in female patients with oral lichen planus

目的 比较口腔扁平苔藓(OLP)女性患者与健康女性人群血清25-羟维生素D_(3)[25-(OH)D_(3)]水平差异,分析血清25-(OH)D_(3)水平与OLP发病机制间的可能关系。方法 选择2018年9月至2019年2月就诊于宁夏医科大学总医院口腔医院口腔黏膜病科的150例口腔扁平苔藓女性患者为OLP组,选择同期来自宁夏医科大学总医院体检中心的健康体检女性150例为健康对照组。抽取两组受试对象5 ml空腹静脉血,采用电化学发光法检测25-(OH)D_(3)水平。结果 OLP组血清25-(OH)D_(3)水平(15.45±6.26)ng/ml显著低于健康对照组(22.95±9.88)ng/ml,差异具有统计学意义(P<0.05);OLP组维生素D缺乏及严重缺乏患者比例(61.3%/16.0%)显著高于健康对照组(42.0%/4.7%),维生素D充足患者比例(5.3%)显著低于健康对照组(21.3%),差异均具有统计学意义(P<0.05)。结论 口腔扁平苔藓的发病是多种因素联合作用的结果,维生素D的缺乏或不足可能参与口腔扁平苔藓疾病的发生和发展。

Objective To determine the serum 25-(OH)D_(3)level in female patients with oral lichen planus(OLP),and to analyze the possible relationship between 25-(OH)D_(3)and the pathogenesis of OLP. Methods A total of 150 female patients diagnosed with OLP and 150 healthy women were collected, and their serum 25-(OH)D_(3)levels were detected and analyzed. Results Serum 25-(OH)D_(3)level of female OLP patients(15.45±6.26)ng/ml was significantly lower than that of healthy women(22.95±9.88)ng/ml and the difference between the two groups was statistically significant(P<0.05).Conclusions The pathogenesis of OLP is the result of a combination of many factors, and vitamin D may play a role in the occurrence and development of OLP.