尖锐湿疣治疗及其可能机制研究进展

RESEARCH PROGRESS ON TREATMENT AND POSSIBLE MECHANISM OF CONDYLOMA ACUMINATUM

尖锐湿疣(condyloma acuminatum,CA)是由人乳头瘤病毒(human papilloma virus,HPV)感染引起的一种性传播疾病。其主要表现为皮肤黏膜的赘生物,可以为疣状、菜花状、鸡冠状及蕈样状。该病的发病率呈逐年上升趋势,目前针对本病的治疗方式包括冷冻、微波、电离子、激光、光动力以及中西医药物治疗等,尽管很多方法有一定疗效,但也容易出现一些不良反应,治疗后的复发率较高。尖锐湿疣的强传播性和高复发率,对患者的生理和心理都产生了极大的负面影响,因此,临床研究越来越重视尖锐湿疣新的治疗方法的探索。本文对近年来尖锐湿疣的临床治疗方法及可能的机制进行综述,为临床治疗提供新的思路。

Condyloma acuminatum is a sexually transmitted disease caused by human papilloma virus(HPV)infection.It is mainly manifested as the excrescences of skin and mucous membrane,which can be wart-shaped,cauliflower shaped,cockscomb shaped and fungoid-shaped.The incidence of the disease is increasing year by year,the current treatment for the disease including freezing,microwave,ion,laser,photodynamic and traditional Chinese and western medicine treatment and other treatment methods,although many methods have a certain effect,but also prone to some adverse reactions,the recurrence rate is high after treatment.The strong transmission and high recurrence rate of condyloma acuminatum has a great negative impact on the physical and psychological of patients[1].Therefore,clinical research is paying more and more attention to the exploration of new treatment methods for condyloma acuminatum.This paper reviews the clinical treatment methods and possible mechanisms of condyloma acuminatum in recent years to provide new ideas for clinical treatment.