三阴性乳腺癌组织中雄激素受体、肿瘤抑制蛋白P53的表达及与预后的关系

Relationship Between the Expression of Androgen Receptor, Tumor Suppressor Protein p53 and Prognosis in Triple Negative Breast Cancer

目的 探讨雄激素受体(AR)、肿瘤抑制蛋白p53(P53)在三阴性乳腺癌(TNBC)组织中的表达及与患者预后的关系。方法 将52例女性TNBC患者纳入观察组,同期收治的50例女性非三阴性乳腺癌(NTNBC)患者纳入对照组,所有患者均经手术病理检查确诊。运用免疫组织化学法检测2组癌组织内的AR、P53表达情况;同时分析AR、P53的表达与TNBC患者临床病理特征的关系。随访3年,以Kaplan-Meier法分析AR、P53表达与TNBC患者预后的关系。结果 观察组的AR阳性表达率低于对照组,P53阳性表达率高于对照组,有统计学差异(P<0.05)。AR、P53的表达与TNBC患者的组织学分级、TNM分期、淋巴结转移有关(P<0.05),与年龄、绝经状态、肿瘤直径无关(P>0.05)。Kaplan-Meier结果显示:AR阴性表达患者的3年生存率[40.63%(13/32)]低于AR阳性表达[75.00%(15/20)],P53阳性表达患者的3年生存率[40.00%(16/40)]低于P53阴性表达[75.00%(9/12)],有统计学差异(P<0.05)。结论 TNBC患者的癌组织内的AR呈阴性表达,P53呈阳性表达,AR、P53的表达与患者的组织学分级、TNM分期、淋巴结转移联系紧密,且AR阴性表达、P53阳性表达患者生存率更低,预后更差。

Objective To investigate the expression of androgen receptor(AR) and tumor suppressor protein p53(p53) in triple negative breast cancer(TNBC) and its relationship with prognosis.Methods 52 female TNBC patients treated were included in the observation group, and 50 female non triple negative breast cancer(ntnbc) patients treated in the same period were included in the control group.All patients were confirmed by surgical and pathological examination.Immunohistochemical method was used to detect the expression of AR and p53 in the 2 groups of cancer tissues;At the same time, the relationship between the expression of AR and p53 and the clinicopathological characteristics of TNBC patients was analyzed;The relationship between the expression of AR and p53 and the prognosis of TNBC patients was analyzed by Kaplan Meier method.Results The positive expression rate of AR in the observation group was lower than that in the control group, and the positive expression rate of p53 was higher than that in the control group(P<0.05);The expression of AR and p53 was related to the histological grade, TNM stage and lymph node metastasis of TNBC patients(P<0.05);The expression of AR and p53 had no correlation with age, menopausal status and tumor diameter(P>0.05);Kaplan Meier results showed that the 3-year survival rate of patients with AR negative expression [40.63%(13/32)] was lower than that of patients with AR positive expression [75.00%(15/20)],and the 3-year survival rate of patients with p53 positive expression [40.00%(16/40)] was lower than that of patients with p53 negative expression [75.00%(9/12)],with statistical difference(P<0.05).Conclusion In TNBC patients, the expression of AR and p53 is negative and positive.The expression of AR and p53 is closely related to the histological grade, TNM stage and lymph node metastasis of patients, and the survival rate of patients with AR negative expression and p53 positive expression is lower and the prognosis is worse.