小金丸现代研究进展及制剂存在问题分析

Modern Research Progress of Xiaojin Pills(小金丸)and Analysis of Existing Problems in Its Preparation

总结分析小金丸的药理作用、临床应用及其制剂存在的问题。小金丸具有抗血小板聚集、抗炎、镇痛、抗乳腺增生、抗肿瘤、增强免疫功能等药理作用,常用于治疗乳腺增生症、乳腺癌、甲状腺结节、前列腺增生、前列腺炎、子宫内膜异位症、带状疱疹后遗神经痛、慢性睾丸痛、阴茎硬结症、小儿肠系膜淋巴结炎等疾病。小金丸原糊丸剂型在制备工艺、质量控制、不良反应等方面存在问题。现代药剂学的新设备、新技术、新辅料可为小金丸制剂二次开发的剂型设计、工艺改进和质量评价提供解决路径,以促进小金丸更好地服务于临床。

To summarize and analyze the pharmacological effects,clinical application and existing problems in its preparation of Xiaojin pills(小金丸).Xiaojin pills has the pharmacological effects of anti-platelet aggregation,anti-inflammation,analgesia,anti-mammary hyperplasia,anti-tumor,and enhancing immune function.It is commonly used in clinic to treat breast hyperplasia,breast cancer,thyroid nodule,prostatic hyperplasia,prostatitis,endometriosis,postherpetic neuralgia,chronic testicular pain,penile sclerosis,children's mesenteric lymphadenitis and other diseases.This paper analyzed the problems,quality and adverse reactions existing in the process of the original paste pills of Xiaojin pills,and put forward that combining the new equipment,new technology and new excipients of modern pharmaceutics will provide a solution for the formulation design,process improvement and quality evaluation of the secondary development of Xiaojin pills,so as to promote the clinical usage better.