原发性乳腺骨肉瘤一例并文献复习

A case of primary breast osteosarcoma and literature review

原发性乳腺骨肉瘤是一种比较罕见的恶性肿瘤,肿块较大且易复发,临床多采用外科手术治疗,辅助放化疗效果尚不明确。报告一例因“发现右乳肿块2年”行“右乳肿块切除术”的73岁老年女性,术后病理联合影像检查结果确诊为原发性乳腺骨肉瘤。1年后因右乳肿块复发并进行性增大行“根治性切除术”,术后给予表柔比星+顺铂化疗4个周期,至今疾病稳定无复发转移。随后回顾了21世纪以来报道的原发性乳腺骨肉瘤病例的治疗和预后。

Primary breast osteosarcoma is a relatively rare malignant tumor,the tumor is large and easy to relapse.Surgical treatment is often used in clinical practice,the effect of adjuvant radiotherapy and chemotherapy is not clear.A73-years-old woman who underwent"right breast mass resection"due to"discovery of right breast mass for 2 years"was diagnosed as primary breast osteosarcoma by postoperative pathology combined with imaging examination.One year later,"radical resection"was performed due to recurrence and progressive enlargement of the right breast mass.After 4 cycles of epirubicin+cisplatin chemotherapy,the disease was stable without recurrence and metastasis.Subsequently,the treatment and prognosis of primary breast osteosarcoma cases reported since the 21 st century were reviewed.