基于超分子化学的核酸表观遗传修饰研究

Study of Epigenetic Modifications of Nucleic Acids Based on Supramolecular Chemistry

核酸是生物体的遗传物质,在生命体系中发挥着重要作用.除了构成核酸的经典碱基之外,核酸中还存在天然修饰的碱基,这被称为核酸的表观遗传修饰.核酸的表观遗传修饰在基因表达过程中具有重要的调控作用,对生物体遗传和生命生长过程影响很大,并且核酸表观遗传与疾病密切相关.超分子化学是研究分子间键的化学,而许多生物分子都需要通过超分子化学作用来发挥其生物功能,可以说生物体内天然存在着大量的超分子化学过程.本文综合评述了基于超分子化学的核酸表观遗传修饰研究的一些代表性工作.

Nucleic acids are the genetic material of living organisms and play important roles in the living system.In addition to the classical bases,there are also naturally modified bases in nucleic acids,which are called epigenetic modifications of nucleic acids.Epigenetic modifications of nucleic acids play an important role in the regulation of gene expression and have a great impact on the genetic and growth processes of organisms,and the nucleic acid epigenetics are closely associated to diseases as well.Supramolecular chemistry study the intermolecular bonds,and many biomolecules perform their biological functions via supramolecular processes,and it can be said that a large number of supramolecular chemical processes naturally exist in living organisms.This paper highlighted some representative work on epigenetic modification of nucleic acids based on supramolecular chemistry.