耐药菌非抗生素疗法研究进展

Advances in Non-antibiotic Therapy for Drug-resistant Bacteria

抗生素耐药性是21世纪人类面临的主要公共卫生威胁之一。抗生素滥用导致越来越多的细菌产生了耐药性,使得传统抗生素治疗面临着巨大挑战。非抗生素治疗策略,如噬菌体疗法、抗菌肽疗法、抗毒力因子疗法等,在应对耐药性细菌方面具有独特的优势与临床潜力,并且能够有效避免细菌耐药性的产生与传播。综述耐药菌非抗生素疗法的研究进展,探讨其在抗感染领域的新型治疗方案。未来,耐药菌非抗生素疗法有望协同乃至替代抗生素疗法,从而应对“抗生素危机”。

Antibiotic resistance has been a serious challenge for human health at the beginning of the 21st century. With the appearance of more and more multi-drug resistant bacteria, traditional antibiotic treatments have been involved in a significant crisis in the last decades. A new non-antibiotic therapeutic strategy, including phage therapy, antimicrobial peptide therapy and anti-virulence factor therapy, has been received more attention in recent years, due to its unique advantages and clinical potential in dealing with bacterial infections, while effectively avoiding the emergence and spread of bacterial resistance. This strategy has been expected to synergize with or even replace traditional antibiotic therapy to fight against this crisis. In this paper, some important concepts and research advances about non-antibiotic therapies in the last decades have been summarized, and the clinical potential and challenges of non-antibiotic therapeutic strategies in the future have also been analyzed.