天然产物姜黄素改善非酒精性脂肪肝的研究进展

Research Progress of Natural Product Curcumin Improving Nonalcoholic Fatty Liver

非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)是一种由多因素应激产生的慢性进行性肝脏疾病,与胰岛素抵抗、高血压、血脂紊乱和脂肪栓塞等疾病密切相关。因为其发生机制复杂,目前没有针对性药物。姜黄素是一种来源于姜黄中的多酚类天然产物,具有降血脂、抗炎和抗氧化等作用。近年来,大量实验证明姜黄素能够通过多种调节方式减轻胰岛素抵抗,抑制氧化应激反应,降低体内炎性因子,减少肝内脂肪沉积,从而有效改善非酒精性脂肪肝,阻断肝纤维化和肝硬化进程。

Non-alcoholic fatty liver disease(NAFLD)is a chronic progressive liver disease caused by multifactor stress,which is closely related to insulin resistance,hypertension,dyslipidemia and fat embolism.Because of its complex mechanism,there are no targeted drugs at present.Curcumin is a natural product of polyphenols derived from curcuma,which has the effects of lowering blood lipids,anti-inflammatory and antioxidant.In recent years,a large number of experiments have proved that curcumin can reduce insulin resistance,inhibit oxidative stress reaction,reduce inflammatory factors in the body,and reduce intrahepatic fat deposition through a variety of regulatory ways,thus effectively improving nonalcoholic fatty liver,blocking the process of liver fibrosis and cirrhosis.