低级别纤维黏液样肉瘤4例临床病理分析

Low grade malignant fibromyxoid sarcoma: clinicopathological analysis of 4 cases

目的 探讨低级别纤维粘液样肉瘤的临床病理特征,诊断和鉴别诊断的要点。方法 对4例低级别纤维粘液样肉瘤进行临床特征和病理学分析,结合文献分析其诊断要点和鉴别诊断。结果 4例患者,男性3例,女性1例,年龄26~70岁,肿瘤分别位于左颈后部,左臀部,左腹股沟及胸壁。组织学上,由形态较温和的短梭形或卵圆形细胞组成,间质呈典型的粘液样与胶原样交替分布。肿瘤细胞表达Vimentin, MUC4。结论 低级别纤维粘液样肉瘤是纤维肉瘤的一种特殊亚型,好发于青年人,通过病例回顾和文献学习掌握这一较少见肿瘤的诊断和鉴别诊断十分必要。

Objective To explore the clinicopathological features, diagnosis and differential diagnosis of low grade malignant fibromyxoid sarcoma. Methods 4 cases of low grade fibromyxoid sarcoma were analyzed clinical data, pathological, and the diagnosis and differential diagnosis were discussed with review of the literature. Results There were 3 males and 1 females with age range from 26 to 70 years. The tumors were located in left posterior neck, left hip, left groin and chest wall respectively. Histologically, the stroma is composed of short fusiform or ovoid cells with a mild appearance, typically alternating between myxoid and gelatinous cells. Tumor cells express Vimentin, MUC4. Conclusion Low-grade malignant fibromyxoid sarcoma is a special subtype of fibrosarcoma, which tends to occur in young people. It is necessary to master the diagnosis and differential diagnosis of this rare tumor through case review and literature study.